Abstract
Writhing reaction of mice has been used for the evaluation of analgesics or anti-inflammatory agents (Vinegar et al., 1979). It has been suggested that there may be a putative involvement of cyclooxygenase metabolites in this model of inflammatory pain. However, it is not yet generally concluded which product of eicosanoids, including PGE2 and PGI2, is a main mediator of this pain model.
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Oh-ishi, S., Ueno, A., Matsumoto, H., Murata, T., Ushikubi, F., Narumiya, S. (1999). Evidence for Involvement of Prostaglandin I2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writhing Reaction: a Study Using IP-Receptor Disrupted Mice. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_39
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DOI: https://doi.org/10.1007/978-1-4615-4793-8_39
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