Abstract
In addition to polypeptide growth factors, an emerging group of naturally occurring phospholipid growth factors has been discovered1. Within this group, lysophosphatidic acid (LPA, l-acyl-2-lyso-sn-glycero-3-phosphate), nature’s simplest phospholipid, was found to elicit growth factory-like effects in almost every cell type spanning the phylogenetic tree, from Dictyostelium to humans. These biological effects include: 1) the mitogenic2 or antimitogenic regulation of the cell cycle3, 2) regulation of Ca2+ homeostasis4. 3) regulation of cell shape5, migration6, and tumor cell invasiveness7, and 4) the prevention of apoptosis8. LPA elicits these effects via multiple G protein-coupled receptors. Here we report that naturally occurring analogs of LPA elicit distinct cellular responses via the selective activation of receptor subligand specificities towards LPA, cyclic-phosphatidic acid (cyclic-PA), and plasmalogenglycerophosphate (alkenyl-GP).
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Tigyi, G. et al. (1999). Determinants of Receptor Subtype Specificity in the LPA-Like Lipid Mediator Family. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_36
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DOI: https://doi.org/10.1007/978-1-4615-4793-8_36
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