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Role of COX-2 Inhibition on the Formation and Healing of Gastric Ulcers Induced by Indomethacin in the Rat

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

The role that the two forms of cyclooxygenase (COX) plays in basal conditions and during the induction and the repair process of gastric lesions is not well understood. Prostaglandins derived from COX-1 are believed to be essential for the maintenance of gastric homeosthasis but, although expressed constitutively, COX-1 can be induced in stomach under certain circumstances1. The expression of COX-2 in normal gastric mucosa remains still controversial but a role for constitutive COX-2 products on the gastroprotective effects evoked by mild irritants such as ethanol has been suggested2.

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Authors and Affiliations

  1. Research Center, Almirall Prodesfarma, Cardener 68-74, Barcelona, 08024, Spain

    Nuria Godessart, Carolina Salcedo, Andrés G. Fernández & José M. Palacios

Authors
  1. Nuria Godessart
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  2. Carolina Salcedo
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  3. Andrés G. Fernández
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  4. José M. Palacios
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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© 1999 Springer Science+Business Media New York

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Godessart, N., Salcedo, C., Fernández, A.G., Palacios, J.M. (1999). Role of COX-2 Inhibition on the Formation and Healing of Gastric Ulcers Induced by Indomethacin in the Rat. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_24

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

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