Abstract
Arachidonic acid metabolism is important in regulating the cerebral circulation and its response to CNS injury (1,2), a response that often involves vascular cell proliferation, inflammatory cell infiltrates, and glial cell reactions. Induction and regulation of cyclooxygenase-2 (COX-2) may be important in these processes. Since a number of pro-and anti-inflammatory cytokines, including TGFβ1, TNFα, and IL-1β, are produced during the course of CNS reaction to injury(3,4,5), we investigated the regulation of cerebrovascular COX-2 expression by these agents. In addition to cytokine production, the release of polyunsaturated fatty acids (PUFA), particularly arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3), is a common early reaction to CNS injury (6,7). Therefore, the potential interactions of PUFA and proinflammatory cytokines in the regulation of COX-2 were also investigated.
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Moore, S.A., Yoder, E., Rich, G., Hilfers, M., Albright, J. (1999). Regulation of Cerebrovascular Cyclooxygenase-2 by Pro- and Anti-Inflammatory Cytokines. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_19
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DOI: https://doi.org/10.1007/978-1-4615-4793-8_19
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