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Structure Function Studies of a New World Monkey

α1,3Galactosyltransferase Analysis of Alternative Splicing and Expression in Baculovirus System

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α-Gal and Anti-Gal

Part of the book series: Subcellular Biochemistry ((SCBI,volume 32))

Abstract

The α1, 3galactosyltransferase (α1,3GT) is one of a growing number of cloned glycosyltransferase enzymes which exhibit a remarkable degree of similarity in their overall structure. The α1,3GT, which was simultaneously cloned from the cow (Joziasse et al., 1989) and the mouse (Larsen et al., 1989), was one of the earliest glycosyltransferases for which complete sequence information was available. Since then, over 40 distinct glycosyltransferase genes have been cloned in humans alone. Without exception, each is organized as a type II transmembrane protein, with an N-terminal end within the cytosol and the C-terminal end protruding into the lumen of the endoplasmic reticulum or the Golgi apparatus.

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Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, Eunice Kennedy Shriver Center, Waltham, Massachusetts, 02254, USA

    T. R. Henion

  2. Department of Microbiology and Immunology, MCP-Hahnemann School of Medicine, Philadelphia, Pennsylvania, 19129, USA

    U. Galili

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  1. T. R. Henion
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  2. U. Galili
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Editors and Affiliations

  1. MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA

    Uri Galili

  2. Institute of Biomedicine, Caracas, Venezuela

    José Luis Avila

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Henion, T.R., Galili, U. (1999). Structure Function Studies of a New World Monkey. In: Galili, U., Avila, J.L. (eds) α-Gal and Anti-Gal. Subcellular Biochemistry, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4771-6_3

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  • DOI: https://doi.org/10.1007/978-1-4615-4771-6_3

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