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Depolarization-Induced Suppression of Inhibition (DSI) Involves a Retrograde Signaling Process that Regulates GABAA-Mediated Synaptic Responses in Mammalian CNS

  • Chapter
The “Drunken” Synapse

Abstract

Regulation of gamma-aminobutyric acid A (GABAA)-receptor-mediated inhibition is important for the control of neuronal excitability in the brain. Decreases in inhibition facilitate the induction of long-term potentiation (LTP) (Wigstrom and Gustafsson, 1983) and long-term depression (LTD) (Wagner and Alger, 1995; Bear and Abraham, 1996). However, if pronounced in magnitude or duration, decreases in GABAAergic inhibition can cause various pathophysiological conditions such as epileptic seizures (Meldrum, 1975) and excitotoxicity (Thompson et al., 1996). A physiologically useful type of inhibitory modulation might be one in which regulation of specific GABAAergic influences would be limited in time and space.

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Authors and Affiliations

  1. Department of Physiology School of Medicine and Program in Neuroscience, University of Maryland, Baltimore, 655 West Baltimore Street, Baltimore, Maryland, 21201, USA

    Bradley E. Alger

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  1. Bradley E. Alger
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  1. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA

    Yuan Liu  & Walter A. Hunt  & 

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Alger, B.E. (1999). Depolarization-Induced Suppression of Inhibition (DSI) Involves a Retrograde Signaling Process that Regulates GABAA-Mediated Synaptic Responses in Mammalian CNS. In: Liu, Y., Hunt, W.A. (eds) The “Drunken” Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4739-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-4739-6_7

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