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The “Drunken” Synapse pp 27–38Cite as

Molecular Targets Underlying Ethanol-Mediated Reduction of Hormone Release from Neurohypophysial Nerve Terminals

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Abstract

In developing a model system in which to study the molecular basis for the acute and chronic actions of ethanol in the nervous system, our basic philosophy has been: 1) to work with a relevant molecular target (i.e., a mediator of a behavioral or physiological consequence of ethanol ingestion), which is 2) amenable to analysis at the molecular level, and in which 3) we can identify the biophysical parameters responsible for acute modulation by the drug. It will also be possible to follow alterations in the function and ethanol response of this target during chronic exposure of the animal to ethanol, and the development of various forms of tolerance in those systems or behaviors subserved by the target molecule.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and the Neuroscience Program, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, Massachusetts, 01655, USA

    Steven N. Treistman, Benson Chu & Alejandro M. Dopico

Authors
  1. Steven N. Treistman
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  2. Benson Chu
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  3. Alejandro M. Dopico
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Editor information

Editors and Affiliations

  1. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA

    Yuan Liu  & Walter A. Hunt  & 

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© 1999 Springer Science+Business Media New York

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Treistman, S.N., Chu, B., Dopico, A.M. (1999). Molecular Targets Underlying Ethanol-Mediated Reduction of Hormone Release from Neurohypophysial Nerve Terminals. In: Liu, Y., Hunt, W.A. (eds) The “Drunken” Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4739-6_3

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  • DOI: https://doi.org/10.1007/978-1-4615-4739-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7148-9

  • Online ISBN: 978-1-4615-4739-6

  • eBook Packages: Springer Book Archive

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