Skip to main content
SpringerLink
Log in

Ethanol Suppression of Hippocampal Plasticity

Role of Subcortical Inputs

  • Chapter
The “Drunken” Synapse

Abstract

In his opening remarks, Shepherd posited the following concept: the behavioral consequences of synaptic transmission are expressed in terms of circuits. In echoing this perspective, our research efforts are devoted to characterizing the functional neuronal ensembles underlying the amnestic, intoxicating, and rewarding properties of alcohol.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amaral DG (1978) A Golgi study of cell types in the hilar region of the hippocampus in the rat. J Comp Neurol 182:851–914.

    Article  PubMed  CAS  Google Scholar 

  • Assaf SY, Miller JJ (1977) Excitatory action of the mesolimbic dopamine system on septal neurones. Brain Res 129:353–360.

    Article  PubMed  CAS  Google Scholar 

  • Baudry M, Arst D, Oliver M, Lynch G (1981) Development of glutamate binding sites and their regulation by calcium in rat hippocampus. Dev Brain Res 1:37–48.

    Article  CAS  Google Scholar 

  • Bekenstein JW, Lothman EW (1991) An in vivo study of the ontogeny of long-term potentiation (LTP) in the CA1 region and in the dentate gyrus of the rat hippocampal formation. Dev Brain Res 63:245–251.

    Article  CAS  Google Scholar 

  • Bilkey DK, Goddard GV (1985) Medial septal facilitation of hippocampal granule cell activity is mediated by inhibition of inhibitory interneurons. Brain Res 361:99–106.

    Article  PubMed  CAS  Google Scholar 

  • Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol (Lond) 232:331–356.

    CAS  Google Scholar 

  • Blitzer RD, Gil O, Landau EM (1990) Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol. Brain Res 537:203–208.

    Article  PubMed  CAS  Google Scholar 

  • Brodie MS, Shefher SA, Dunwiddie TV (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508:65–69.

    Article  PubMed  CAS  Google Scholar 

  • Bronzino JD, Abu-Hasaballah RJ, Austin-LaFrance RJ, Morgane PJ (1994) Maturation of long-term potentiation in the hippocampal dentate gyrus of the freely moving rat. Hippocampus 4:439–446.

    Article  PubMed  CAS  Google Scholar 

  • Buzsaki G, Gage F (1987) Absence of long-term potentiation in the subcortically deafferented dentate gyrus. Brain Res 484:94–101.

    Article  Google Scholar 

  • Buzsaki G, Ponomareff GL, Bayardo F, Ruiz R, Gage FH (1989) Neuronal activity in the subcortically denervated hippocampus: A chronic model for epilepsy. Neuroscience 28:527–538.

    Article  PubMed  CAS  Google Scholar 

  • Criado JR, Steffensen SC, Henriksen SJ (1994) Ethanol acts via the ventral tegmental area to influence hippocampal physiology. Synapse 17:84–91.

    Article  PubMed  CAS  Google Scholar 

  • Criado JR, Steffensen SC, Henriksen SJ (1994) Mesolimbic Dopaminergic modulation of synaptic transmission in the dentate gyrus is mediated through the septal nucleus. Soc Neurosci Abst 20:530.

    Google Scholar 

  • Criado JR, Steffensen SC, Henriksen SJ (1996) Microelectrophoretic application of SCH-23390 into the lateral septum nucleus blocks ethanol-induced suppression of LTP, in vivo, in the adult rodent hippocampus. Brain Res 716:192–196.

    Article  PubMed  CAS  Google Scholar 

  • Gessa G, Muntoni F, Boi V, Mereu G (1985) Effects of Ethanol on Mid-Brain Dopamine and NON-Dopamine Neurons. Soc Neurosci Abst 11:87.14.

    Google Scholar 

  • Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons of the ventral tegmental area. Brain Res 348:201–204.

    Article  PubMed  CAS  Google Scholar 

  • Givens B (1995) Low doses of ethanol impair spatial working memory and reduce hippocampal theta activity. Alcoholism Clin Exp Res 19:763–767.

    Article  CAS  Google Scholar 

  • Hokfelt T, Fuxe K, Johansson O, Ljungdahl A (1974) Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex. Eur J Pharmacol 25:108–112.

    Article  PubMed  CAS  Google Scholar 

  • Izumi Y, Zorumski CF (1995) Developmental changes in long-term potentiation in CA1 of rat hippocampal slices. Synapse 20:19–23.

    Article  PubMed  CAS  Google Scholar 

  • Knowles WD, Schwartzkroin PA (1981) Local circuit interactions in hippocampal brain slices. J Neurosci 1:318–322.

    PubMed  CAS  Google Scholar 

  • Koob G, Strecker R, Bloom FE (1980) Substance Alcohol Actions/Misuse 1:447–457.

    CAS  Google Scholar 

  • Koob GF (1992) dopamine, addiction and reward. Semin Neurosci 4:139–148.

    Article  Google Scholar 

  • Kosaka T, Kosaka K, Tateishi K, Hamaoka Y, Yanaihara N, Wu J-Y, Hama K (1985) GABAergic neurons containing CCK-8-like and/or VIP-like immunoreactivities in the rat hippocampus and dentate gyrus. J Comp Neurol 239:420–430.

    Article  PubMed  CAS  Google Scholar 

  • Lacaille J-C, Mueller AL, Kunkel DD, Schwartzkroin PA (1987) Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology. J Neurosci 7:1979–1993.

    PubMed  CAS  Google Scholar 

  • Laurberg S, Sorensen JE (1981) Associational and commissural collaterals of neurons in the hippocampal formation (hilus fasciae dentate and subfield CA3). Brain Res 212:287–300.

    Article  PubMed  CAS  Google Scholar 

  • Lister RG, Eckardt MJ, Weingartner H (1987) Ethanol intoxication and memory: Recent developments and new directions. In: Recent Developments in Alcoholism, (Galanter M, ed), pp 111–126. New York: Plenum Press.

    Google Scholar 

  • Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion currents in hippocampal neurons. Science 243:1721–1724.

    Article  PubMed  CAS  Google Scholar 

  • Mereu G, Fadda F, Gessa GL (1984) Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanes-thetized rats. Brain Res 292:63–69.

    Article  PubMed  CAS  Google Scholar 

  • Michelson HB, Lothman EW (1989) An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampus. Dev Brain Res 47:113–122.

    Article  CAS  Google Scholar 

  • Mizumori SJY, McNaughton BL, Barnes CA (1989) A comparison of supramammillary and medial septal influences on hippocampal field potentials and single-unit activity. J Neurophysiol 61:15–31.

    PubMed  CAS  Google Scholar 

  • Morris RGM, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774–776.

    Article  PubMed  CAS  Google Scholar 

  • Morrisett RA, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS (1990) Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Dev Brain Res 56:257–262.

    Article  CAS  Google Scholar 

  • Morrisett RA, Swartzwelder HS (1993) Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. J Neurosci 13:2264–2272.

    PubMed  CAS  Google Scholar 

  • Ribak C, Vaughn J, Saito K (1978) Immunocytological localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport. Brain Res 140:315–322.

    Article  PubMed  CAS  Google Scholar 

  • Robinson GB, Racine RJ (1982) Heterosynaptic interactions between septal and entorhinal inputs to the dentate gyms: long-term potentiation effects. Brain Res 249:162–166.

    Article  PubMed  CAS  Google Scholar 

  • Robinson SE, Malthe-Sorenssen D, Wood PL, Commissiong J (1979) dopaminergic control of the septal-hippocampal cholinergic pathway. J Pharm Exp Ther 208:476–479.

    CAS  Google Scholar 

  • Scatton B, Simon H, Le Moal M, Bischoff S (1980) Origin of dopaminergic innervation of the rat hippocampal formation. Neurosci Lett 18:125–131.

    Article  PubMed  CAS  Google Scholar 

  • Scharfman HE, Schwartzkroin PA (1988) Electrophysiology of morphologically identified mossy cells of the dentate hilus recorded in guinea pig hippocampal slices. J Neurosci 8:3812–3821.

    PubMed  CAS  Google Scholar 

  • Schwartzkroin PA, Scharfman HE, Sloviter RS (1990) Similarities in circuitry between Ammon’s horn and dentate gyrus: local interactions and parallel processing. In: Progress in Brain Research, ed), pp 269–286.

    Google Scholar 

  • Simon H, Scatton B, Le Moal M (1980) dopaminergic A10 neurones are involved in cognitive functions. Nature 286:150–151.

    Article  PubMed  CAS  Google Scholar 

  • Steffensen SC, Svingos AL, Pickel VM, Henriksen SJ (1998) Electrophysiological characterization GABAergic neurons in the ventral tegmental area. J. Neurosci 18:8803–8815.

    Google Scholar 

  • Steffensen SC, Yeckel M, Miller DR, Henriksen SJ (1993) Ethanol-induced suppression of hippocampal long-term potentiation is blocked by lesions of the septohippocampal nucleus. Alcohol Clin Exp Res 17:655–659.

    Article  PubMed  CAS  Google Scholar 

  • Swanson LW (1982) The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. Brain Res Bull 9:321–353.

    Article  PubMed  CAS  Google Scholar 

  • Swartzwelder HS, Wilson WA, Tayyeb MI (1995) Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res 19:320–323.

    Article  PubMed  CAS  Google Scholar 

  • Williams K, Russell S, Shen Y, Molinoff P (1993) Developmental switch in expression of NMDA receptors occurs in vivo and in vitro. Neuron 10:267–278.

    Article  PubMed  CAS  Google Scholar 

  • Yanagihashi R, Ishikawa T (1992) Studies on long-term potentiation of the population spike component of hippocampal field potential by the tetanic stimulation of the perforant path in rats: effects of a dopamine agonist, SKF-38393. Brain Res 579:79–86.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuropharmacology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    Scott C. Steffensen

Authors
  1. Scott C. Steffensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA

    Yuan Liu  & Walter A. Hunt  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Steffensen, S.C. (1999). Ethanol Suppression of Hippocampal Plasticity. In: Liu, Y., Hunt, W.A. (eds) The “Drunken” Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4739-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4739-6_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7148-9

  • Online ISBN: 978-1-4615-4739-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation