Skip to main content

Fetal Bladder Physiology

  • Chapter
Advances in Bladder Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 462))

Abstract

The function of the bladder is to store urine at a low pressure and then to periodically expel the urine via coordinated and sustained contractions. Failure of the bladder to perform these functions will result in abnormally high pressure transmitted to the kidneys resulting in renal damage. The process by which the bladder acquires these important functions remains to be fully understood. Much research has been dedicated to understanding the physiology of the fetal lower urinary tract. Currently, the methods of studying the fetal lower urinary tract are those in which the human fetus is observed by ultrasound, histologic and physiologic measurements are made in whole organ preparation or muscle strip studies, and physiologic measurements are made in an animal preparation. In this chapter, we will summarize our current understanding of fetal bladder physiology based on studies in the human fetus and animal preparations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Grannum P.A.: The Genitourinary Tract, in DA Nyberg, Mahony BS and Pretorius DH: Diagnostic Ultrasound of Fetal Anomalies: Text and Altas. Chicago, Year Book Medical Publishers Inc., 433, 1990.

    Google Scholar 

  2. Hata T. and Deter R.L.: A review of fetal organ measurements obtained with ultrasound: normal growth. J. Clin. Ultrasound., 20: 155, 1992.

    Article  PubMed  CAS  Google Scholar 

  3. Rabinowitz R., Peters M.T., Vyas S., Campbell S. and Nicolaides K.H.: Measurement of fetal urine production in normal pregnancy by real-time ultrasonography. Am. J. Obstet. Gynecol., 161: 1264, 1989.

    PubMed  CAS  Google Scholar 

  4. Ohel G., Haddad S. and Samueloff A.: Fetal urine production and micturition and fetal behavioral state., Am. J. Perinatol., 12: 91, 1995.

    Article  PubMed  CAS  Google Scholar 

  5. Keating M.A., Duckett J.W., Snyder H.M., Wein A.J., Potter L. and Levin R.M.: Ontogeny of bladder function in the rabbit. J. Urol., 144: 766, 1990.

    PubMed  CAS  Google Scholar 

  6. Copien D.E, Macarak E.J. and Levin R.M.: Developmental changes in normal fetal bovine whole bladder physiology. J. Urol., 151: 1391, 1994.

    Google Scholar 

  7. Koo H.P., Macarak E.J., Zderic S.A., Duckett J.W., Synder H.Mr, and Levin R.M.: The ontogeny of bladder function in the fetal calf. J. Urol., 154: 283, 1995.

    Article  PubMed  CAS  Google Scholar 

  8. Baskin L., Meaney D., Landsman A., Zderic S.A. and Macarak E.: Bovine bladder compliance increases with normal fetal development. J. Urol., 152: 692; discussion 696, 1994.

    PubMed  CAS  Google Scholar 

  9. Shapiro E., Becich M.J., Periman E. and Lepor H.: Bladder wall abnormalities in myelodysplastic bladders: a computer assisted morphometric analysis. J. Urol., 145: 1024, 1991.

    PubMed  CAS  Google Scholar 

  10. Mayo M.E. and Hinman F.: Structure and function of the rabbit bladder altered by chronic obstruction or cystitis. Invest Urol., 14: 6, 1976.

    PubMed  CAS  Google Scholar 

  11. Susset J.G., Servot-Viguier D., Lamy F., Madernas P. and Black R.: Collagen in 155 human bladders. Invest. Urol., 16:204, 1978.

    PubMed  CAS  Google Scholar 

  12. Gilpin S.A., Gosling J.A. and Barnard R.J.: Morphological and morphometric studies of the human obstructed, trabeculated urinary bladder. Br. J. Urol., 57: 525, 1985.

    Article  PubMed  CAS  Google Scholar 

  13. Kim K.M., Kogan B.A., Massad C.A. and Huang Y-C.: Collagen and elastin in the normal fetal bladder. J. Urol., 146: 524, 1991.

    PubMed  CAS  Google Scholar 

  14. Koo H.P., Howard P.S., Chang S.L., Snyder H.M., Ducket J.W. and Macarak E.J.: Developmental expression of interstitial collagen genes in fetal bladders. J. Urol., 158: 954, 1997.

    Article  PubMed  CAS  Google Scholar 

  15. Dean G.E., Cargill R.Sr., Macarak E., Snyder H.M., Duckett J.W. and Levin R.: Active and passive compliance of the fetal bovine bladder. J. Urol., 158: 1094, 1997.

    Article  PubMed  CAS  Google Scholar 

  16. Levin R.M., Malkowicz S.B., Jacobowitz D. and Wein A.J.: The ontogeny of the autonomic innervation and contractile response of the rabbit urinary bladder. J. Pharmacol. Exp. Then, 219: 250, 1981.

    CAS  Google Scholar 

  17. Zderic S.A., Duckett J.W., Wein A.J., Snyder H.Md. and Levin R.M.: Development factors in the contractile response of the rabbit bladder to both autonomic and non-autonomic agents. Pharmacology, 41: 119, 1990.

    Article  PubMed  CAS  Google Scholar 

  18. Zderic S.A., Hypolite J., Duckett J.W., Snyder H.Md., Wein A.J. and Levin R.M.: Developmental aspects of bladder contractile function: sensitivity to extracellular calcium. Pharmacology, 43: 61, 1991.

    Article  PubMed  CAS  Google Scholar 

  19. Zderic S.A., Sillen U., Liu G.H., Snyder Hd., Duckett J.W., Wein A.J. and Levin R.M.: Developmental aspects of bladder contractile function: evidence for an intracellular calcium pool. J. Urol., 150: 623, 1993.

    PubMed  CAS  Google Scholar 

  20. Zderic S.A., Sillen U., Liu G.H., Snyder M.Cr., Duckett J.W., Gong C. and Levin R.M.: Developmental aspects of excitation contraction coupling of rabbit bladder smooth muscle. J. Urol., 152: 679, 1994.

    PubMed  CAS  Google Scholar 

  21. Gong C., Zderic S.A. and Levin R.M.: Ontogeny of the ryanodine receptor in rabbit urinary bladder smooth muscle. Mol. Cell Biochem., 137: 169, 1994.

    Article  PubMed  CAS  Google Scholar 

  22. Lee J.G., Copien D., Macarak E., Wein A.J. and Levin R.M.: Comparative studies on the ontogeny and autonomic responses of the fetal calf bladder at different stages of development: involvement of nitric oxide on field stimulated relaxation. J. Urol., 151: 1096, 1994.

    PubMed  CAS  Google Scholar 

  23. Kogan B.A. and Iwamoto H.S.: Lower urinary tract function in the sheep fetus: studies of autonomic control and pharmacologic responses of the fetal bladder. J. Urol., 141: 1019, 1989.

    PubMed  CAS  Google Scholar 

  24. Mevorach R.A., Bogaert G.A. and Kogan B.A.: Role of nitric oxide in fetal lower urinary tract function. J. Urol., 152: 510, 1994.

    PubMed  CAS  Google Scholar 

  25. Wlodek M.E., Thorburn G.D. and Harding R.: Bladder contractions and micturition in fetal sheep: their relation to behavioral states. Am. J. Physiol., 257: R1526, 1989.

    PubMed  CAS  Google Scholar 

  26. Kim K.M., Kogan B.A., Massad C.A. and Huang Y-C.: Collagen and elastin in the obstructed fetal bladder. J. Urol., 146: 528, 1991.

    PubMed  CAS  Google Scholar 

  27. Freedman A.L., Qureshi F., Shapiro E., Lepor H., Jacques S.M., Evans M.I., Smith C.A., Gonzalez R. and Johnson M.P.: Smooth muscle development in the obstructed fetal bladder. Urology, 49: 104, 1997.

    Article  PubMed  CAS  Google Scholar 

  28. Peters C.A., Vasavada S., Dator D., Carr M., Shapiro E., Lepor H., McConnell J., Retik A.B. and Mandell J.: The effect of obstruction on the developing bladder. J. Urol., 148: 491, 1992.

    PubMed  CAS  Google Scholar 

  29. Karim O.M., Cendron M., Mostwin J.L. and Gearhart J.P.: Developmental alterations in the fetal lamb bladder subjected to partial urethral obstruction in utero. J. Urol., 150: 1060, 1993.

    PubMed  CAS  Google Scholar 

  30. Peters C.A., Freeman M.R., Fernandez C.A., Shepard J., Wiederschain D.G. and Moses M.A.: Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease. Am. J. Physiol., 272: R1960, 1997.

    PubMed  CAS  Google Scholar 

  31. Rohrmann D., Monson F.C., Damaser M.S., Levin R.M., Duckett J.W., Jr. and Zderic S.A.: Partial bladder outlet obstruction in the fetal rabbit. J. Urol., 158:1071, 1997.

    Article  PubMed  CAS  Google Scholar 

  32. Rohrmann D., Zderic S.A., Duckett J.W., Jr., Levin R.M. and Damaser M.S.: Compliance of the obstructed fetal rabbit bladder. Neurourol. Urodyn., 16:179, 1997.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Nguyen, H.T., Kogan, B.A. (1999). Fetal Bladder Physiology. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4737-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7147-2

  • Online ISBN: 978-1-4615-4737-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics