Abstract
The function of the bladder is to store urine at a low pressure and then to periodically expel the urine via coordinated and sustained contractions. Failure of the bladder to perform these functions will result in abnormally high pressure transmitted to the kidneys resulting in renal damage. The process by which the bladder acquires these important functions remains to be fully understood. Much research has been dedicated to understanding the physiology of the fetal lower urinary tract. Currently, the methods of studying the fetal lower urinary tract are those in which the human fetus is observed by ultrasound, histologic and physiologic measurements are made in whole organ preparation or muscle strip studies, and physiologic measurements are made in an animal preparation. In this chapter, we will summarize our current understanding of fetal bladder physiology based on studies in the human fetus and animal preparations.
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References
Grannum P.A.: The Genitourinary Tract, in DA Nyberg, Mahony BS and Pretorius DH: Diagnostic Ultrasound of Fetal Anomalies: Text and Altas. Chicago, Year Book Medical Publishers Inc., 433, 1990.
Hata T. and Deter R.L.: A review of fetal organ measurements obtained with ultrasound: normal growth. J. Clin. Ultrasound., 20: 155, 1992.
Rabinowitz R., Peters M.T., Vyas S., Campbell S. and Nicolaides K.H.: Measurement of fetal urine production in normal pregnancy by real-time ultrasonography. Am. J. Obstet. Gynecol., 161: 1264, 1989.
Ohel G., Haddad S. and Samueloff A.: Fetal urine production and micturition and fetal behavioral state., Am. J. Perinatol., 12: 91, 1995.
Keating M.A., Duckett J.W., Snyder H.M., Wein A.J., Potter L. and Levin R.M.: Ontogeny of bladder function in the rabbit. J. Urol., 144: 766, 1990.
Copien D.E, Macarak E.J. and Levin R.M.: Developmental changes in normal fetal bovine whole bladder physiology. J. Urol., 151: 1391, 1994.
Koo H.P., Macarak E.J., Zderic S.A., Duckett J.W., Synder H.Mr, and Levin R.M.: The ontogeny of bladder function in the fetal calf. J. Urol., 154: 283, 1995.
Baskin L., Meaney D., Landsman A., Zderic S.A. and Macarak E.: Bovine bladder compliance increases with normal fetal development. J. Urol., 152: 692; discussion 696, 1994.
Shapiro E., Becich M.J., Periman E. and Lepor H.: Bladder wall abnormalities in myelodysplastic bladders: a computer assisted morphometric analysis. J. Urol., 145: 1024, 1991.
Mayo M.E. and Hinman F.: Structure and function of the rabbit bladder altered by chronic obstruction or cystitis. Invest Urol., 14: 6, 1976.
Susset J.G., Servot-Viguier D., Lamy F., Madernas P. and Black R.: Collagen in 155 human bladders. Invest. Urol., 16:204, 1978.
Gilpin S.A., Gosling J.A. and Barnard R.J.: Morphological and morphometric studies of the human obstructed, trabeculated urinary bladder. Br. J. Urol., 57: 525, 1985.
Kim K.M., Kogan B.A., Massad C.A. and Huang Y-C.: Collagen and elastin in the normal fetal bladder. J. Urol., 146: 524, 1991.
Koo H.P., Howard P.S., Chang S.L., Snyder H.M., Ducket J.W. and Macarak E.J.: Developmental expression of interstitial collagen genes in fetal bladders. J. Urol., 158: 954, 1997.
Dean G.E., Cargill R.Sr., Macarak E., Snyder H.M., Duckett J.W. and Levin R.: Active and passive compliance of the fetal bovine bladder. J. Urol., 158: 1094, 1997.
Levin R.M., Malkowicz S.B., Jacobowitz D. and Wein A.J.: The ontogeny of the autonomic innervation and contractile response of the rabbit urinary bladder. J. Pharmacol. Exp. Then, 219: 250, 1981.
Zderic S.A., Duckett J.W., Wein A.J., Snyder H.Md. and Levin R.M.: Development factors in the contractile response of the rabbit bladder to both autonomic and non-autonomic agents. Pharmacology, 41: 119, 1990.
Zderic S.A., Hypolite J., Duckett J.W., Snyder H.Md., Wein A.J. and Levin R.M.: Developmental aspects of bladder contractile function: sensitivity to extracellular calcium. Pharmacology, 43: 61, 1991.
Zderic S.A., Sillen U., Liu G.H., Snyder Hd., Duckett J.W., Wein A.J. and Levin R.M.: Developmental aspects of bladder contractile function: evidence for an intracellular calcium pool. J. Urol., 150: 623, 1993.
Zderic S.A., Sillen U., Liu G.H., Snyder M.Cr., Duckett J.W., Gong C. and Levin R.M.: Developmental aspects of excitation contraction coupling of rabbit bladder smooth muscle. J. Urol., 152: 679, 1994.
Gong C., Zderic S.A. and Levin R.M.: Ontogeny of the ryanodine receptor in rabbit urinary bladder smooth muscle. Mol. Cell Biochem., 137: 169, 1994.
Lee J.G., Copien D., Macarak E., Wein A.J. and Levin R.M.: Comparative studies on the ontogeny and autonomic responses of the fetal calf bladder at different stages of development: involvement of nitric oxide on field stimulated relaxation. J. Urol., 151: 1096, 1994.
Kogan B.A. and Iwamoto H.S.: Lower urinary tract function in the sheep fetus: studies of autonomic control and pharmacologic responses of the fetal bladder. J. Urol., 141: 1019, 1989.
Mevorach R.A., Bogaert G.A. and Kogan B.A.: Role of nitric oxide in fetal lower urinary tract function. J. Urol., 152: 510, 1994.
Wlodek M.E., Thorburn G.D. and Harding R.: Bladder contractions and micturition in fetal sheep: their relation to behavioral states. Am. J. Physiol., 257: R1526, 1989.
Kim K.M., Kogan B.A., Massad C.A. and Huang Y-C.: Collagen and elastin in the obstructed fetal bladder. J. Urol., 146: 528, 1991.
Freedman A.L., Qureshi F., Shapiro E., Lepor H., Jacques S.M., Evans M.I., Smith C.A., Gonzalez R. and Johnson M.P.: Smooth muscle development in the obstructed fetal bladder. Urology, 49: 104, 1997.
Peters C.A., Vasavada S., Dator D., Carr M., Shapiro E., Lepor H., McConnell J., Retik A.B. and Mandell J.: The effect of obstruction on the developing bladder. J. Urol., 148: 491, 1992.
Karim O.M., Cendron M., Mostwin J.L. and Gearhart J.P.: Developmental alterations in the fetal lamb bladder subjected to partial urethral obstruction in utero. J. Urol., 150: 1060, 1993.
Peters C.A., Freeman M.R., Fernandez C.A., Shepard J., Wiederschain D.G. and Moses M.A.: Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease. Am. J. Physiol., 272: R1960, 1997.
Rohrmann D., Monson F.C., Damaser M.S., Levin R.M., Duckett J.W., Jr. and Zderic S.A.: Partial bladder outlet obstruction in the fetal rabbit. J. Urol., 158:1071, 1997.
Rohrmann D., Zderic S.A., Duckett J.W., Jr., Levin R.M. and Damaser M.S.: Compliance of the obstructed fetal rabbit bladder. Neurourol. Urodyn., 16:179, 1997.
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Nguyen, H.T., Kogan, B.A. (1999). Fetal Bladder Physiology. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_9
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DOI: https://doi.org/10.1007/978-1-4615-4737-2_9
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