Abstract
Urinary tract infections (UTIs) are among the most common of urologic and bacterial diseases, ranging from asymptomatic bacteriuria to severe kidney infection and occasional renal failure.1 Acute lower UTIs affect an estimated 10–20% of American women during their lifetime and result in over 5 million office visits to physicians, costing nearly $1 billion annually for diagnosis and treatment.2–4 Approximately 20 percent of these women have frequent (3–6 per year) recurrences of infection following the initial episode, producing additional morbidity and time lost from work;5 these cases of recurrent UTIs cost the health care system at least $200—350 million annually.4–5 Additionally, 1.5 million cases of more advanced forms of UTIs, including cystitis and acute pyelonephritis, necessitate hospitalization costing over $4 billion.1 The bacteria responsible for UTIs are normally present in the bowel, however, the factors mediating their ability to colonize, invade and damage the urinary tract are not well known. Research leading to improved prevention or treatment at the early stages of disease progression can result in significant savings to the health care system.
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Schaeffer, A.J., Rajan, N., Wright, E.T., Duncan, J.L., Anderson, B.E. (1999). Role of Vaginal Colonization in Urinary Tract Infections (UTIs). In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_26
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