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Advances in Bladder Research pp 339–349Cite as

Role of Vaginal Colonization in Urinary Tract Infections (UTIs)

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 462))

Abstract

Urinary tract infections (UTIs) are among the most common of urologic and bacterial diseases, ranging from asymptomatic bacteriuria to severe kidney infection and occasional renal failure.1 Acute lower UTIs affect an estimated 10–20% of American women during their lifetime and result in over 5 million office visits to physicians, costing nearly $1 billion annually for diagnosis and treatment.2–4 Approximately 20 percent of these women have frequent (3–6 per year) recurrences of infection following the initial episode, producing additional morbidity and time lost from work;5 these cases of recurrent UTIs cost the health care system at least $200—350 million annually.4–5 Additionally, 1.5 million cases of more advanced forms of UTIs, including cystitis and acute pyelonephritis, necessitate hospitalization costing over $4 billion.1 The bacteria responsible for UTIs are normally present in the bowel, however, the factors mediating their ability to colonize, invade and damage the urinary tract are not well known. Research leading to improved prevention or treatment at the early stages of disease progression can result in significant savings to the health care system.

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References

  1. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, The National Kidney and Urologie Diseases Advisory Board 1990 Long-Range Plan Window on the 21st Century, NIH Publication Number 90–583, March 1990.

    Google Scholar 

  2. Kass, E.H., Savage, W., Santamarina, B.E.: The significance of bacteriuria in preventive medicine. In: Progress in Pyelonephritis. Edited by E.H. Kass. Philadelphia: F.A. Davis Co., pp. 3–10, 1965.

    Google Scholar 

  3. Cypress, B.K.: Patients’ reasons for visiting physicians: National Ambulatory Medical Care Survey. In: Vital and Health Statistics, Data from the National Health Survey, Series 13; no. 56 [DHHS Publ.; no. (PHS) 82–1717], Hyattsville, Maryland: National Center for Health Statistics, 1981.

    Google Scholar 

  4. Johnson, J.R., Stamm, W.E.: Urinary tract infections in women: Diagnosis and treatment. Ann. Int. Med., 111: 906, 1989.

    PubMed  CAS  Google Scholar 

  5. Stamm, W.E., Hooton, T.M., Johnson, J.R., Johnson, C., Stapleton, A., Roberts, P.L., Moseley, S.L., Fihn, S.D.: Urinary tract infections: From pathogenesis to treatment. J. Infect. Dis., 159: 400, 1989.

    Article  PubMed  CAS  Google Scholar 

  6. Kunin, C.M.: An overview of urinary tract infections. In: Detection, prevention and management of urinary tract infections. Edited by C.M. Kunin. Philadelphia: Lea & Febiger, pp. 125–126, 1987.

    Google Scholar 

  7. Stapleton, A., Moseley, S., Stamm, W.E.: Urovirulence determinants in Escherichia coli isolates causing first-episode and recurrent cystitis in women. J. Infect. Dis., 163: 773, 1991.

    Article  PubMed  CAS  Google Scholar 

  8. Eden, C.S., Hagberg, L., Hanson, L., Hull, S., Hull, R., Jodal, U., Leffler, H., Lomberg, H., Straube, E.: Bacterial adherence — a pathogenic mechanism in urinary tract infections caused by Escherichia coli. Prog. Allergy, 33: 175, 1983.

    Google Scholar 

  9. Arthur, M., Johnson, C.E., Rubin, R.H., Arbeit, R.D., Campanelli, C., Kim, C., Steinbach, S., Agarwal, M., Wilkinson, R., Goldstein, R.: Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenic Escherichia coli. Infect. Immun., 57: 303, 1989.

    PubMed  CAS  Google Scholar 

  10. Hacker, J., Schrettenbrunner, A., Schroter, H., Duvel, H., Schmidt, G., Goebel, W.: Characterization of Escherichia coli wild-type strains by means of agglutination with antisera raised against cloned P-, S- and MS-fimbriae antigens, hemagglutination, serotyping and hemolysin production, Zbl. Bakt. Hyg., A261: 219, 1986.

    Google Scholar 

  11. Johnson, J.R.: Virulence factors in Escherichia coli urinary tract infection. Clin. Micro. Rev., 4: 80, 1991.

    PubMed  CAS  Google Scholar 

  12. Linstedt, R., Larson, G., Falk, P., Jodal, U., Leffler, H., Svanborg, C.: The receptor repertoire defines the host range for attaching Escherichia coli strains that recognize Globo-A. Infect. Immun., 59: 1086, 1991.

    Google Scholar 

  13. Nowicki, B., Svanborg-Eden, C., Hull, R., Hull, S.: Molecular analysis and epidemiology of the Dr hemagglutinin or uropathogenic Escherichia coli. Infect. Immun., 57: 446, 1989.

    PubMed  CAS  Google Scholar 

  14. Stromberg, N., Nyholm, P.-G., Pascher, I., Normark, S.: Saccharide orientation at the cell surface affects glycolipid receptor function. Proc. Natl. Acad. Sci. USA, 88: 9340, 1991.

    Article  PubMed  CAS  Google Scholar 

  15. Korhonen, T.K., Vaisanen-Rhen, V., Rhen, M., Pere, A., Parkkinen, J., Finne, J.: Escherichia coli fimbriae recognizing sialyl galactosides. J. Bacteriol., 159: 762, 1984.

    PubMed  CAS  Google Scholar 

  16. Duid, J.P., Clegg, S., Wilson, M.I.: The fimbrial and nonfimbrial haemagglutinins of Escherichia coli, J. Med. Microbiol., 12: 213, 1979.

    Article  Google Scholar 

  17. Kallenius, G., Svenson, S.B., Hultberg, H., Mollby, R., Helin, I., Cedergren, B., Winberg, J.: Occurrence of P-fimbriated Escherichia coli in urinary tract infections. Lancet, ii: 1369, 1982.

    Google Scholar 

  18. Pere, A., Nowicki, B., Saxen, H., Siitonen, A., Korhonen, T.K.: Expression of P, type-1 and type-1C fimbriae of Escherichia coli in the urine of patients with acute urinary tract infections. J. Infect. Dis., 156: 567, 1987.

    Article  PubMed  CAS  Google Scholar 

  19. Kisielius, P.V., Schwan, W.R., Amundsen, S.K., Duncan, J.L., Schaeffer, A.J.: In vivo expression and variation of Escherichia coli type 1 and P pili in the urine of adults with acute urinary tract infections. Infect. Immun., 57: 1656, 1989.

    PubMed  CAS  Google Scholar 

  20. Neu, H.C.; Urinary tract infections. Am. J. Med., 92: 63, 1992

    Article  Google Scholar 

  21. Stamey, T.A., Timothy, M., Millar, M., Mihara, G.: Recurrent urinary infections in adult women: The role of introital enterobacteria. Calif. Med. 115: 1, 1971.

    PubMed  CAS  Google Scholar 

  22. Stamey, T.A., Sexton, C.C.: The role of vaginal colonization with Enterobacteriaceae in recurrent urinary infections. J. Urol., 113: 214, 1975.

    PubMed  CAS  Google Scholar 

  23. Smith, H.W.: Microbial surfaces in relation to pathogenicity. Bacteriol. Rev. 41: 475, 1977.

    PubMed  CAS  Google Scholar 

  24. Ofek, J., Beachey, E.H.: General concepts and principles of bacterial adherence in animals and men. In: Bacterial Adherence. London: Chapman and Hall, pp. 3–29, 1980.

    Google Scholar 

  25. Savage, D.C. In: Microbial Pathogenicity in Man and Animals. Edited by H. Smith, J.H. Pierce. London: Cambridge Press, pp. 25–57, 1972.

    Google Scholar 

  26. Schaeffer, A.J.: Cystitis and Pyelonephritis. In: The Biologic and Clinical Basis of Infectious Diseases. Edited by G.P. Youmans, P.Y. Paterson, H.M. Sommers. Philadelphia: W.B. Saunders Publishers, pp. 418–35, 1985.

    Google Scholar 

  27. Fowler, J.E., Stamey, T.A.: Studies of introital colonization in women with recurrent urinary infections. J. Urol., 117: 472, 1977.

    PubMed  Google Scholar 

  28. Schaeffer, A.J., Jones, J.M., Dunn, J.K.: Association of in vitro Escherichia coli adherence to vaginal and buccal epithelial cells with susceptibility to women to recurrent urinary tract infections. N. Engl. J. Med., 304: 1062, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Schaeffer, A. J., Amundsen, S.K., Schmidt, L.N.: Adherence of Escherichia coli to human urinary tract epithelial cell. Infect. Immun. Dis., 24: 753, 1979.

    CAS  Google Scholar 

  30. Raz, R., Stamm, W.E.: A controlled trial on intravaginal estriol in postmenopausal women with recurrent urinary tract infection. N. Engl. J. Med., 329: 753, 1993.

    Article  PubMed  CAS  Google Scholar 

  31. Strous, G.J., Dekker, J.: Mucin-type glycoproteins. Crit. Rev. Bioch. Mol. Biol., 27: 57, 1992.

    Article  CAS  Google Scholar 

  32. Allen, A.: Structure of gastrointestinal fluid glycoproteins and the viscous and gel-forming properties of fluid. Br. Med. Bull., 34: 28, 1987.

    Google Scholar 

  33. Carlstedt, I., Sheehan, J.K.: Structure and macromolecular properties of cervical fluid glycoproteins. In: Fluid and Related Topics. Edited by E. Chandler, N.A. Radcliffe. Cambridge: University of Cambridge. Symp. Soc. Exp. Biol. 43: 289, 1989.

    Google Scholar 

  34. Thornton, D.J., Davies, J.R., Kraayenbrink, M., Richardson, P.S., Sheehan, J.K., Carlstedt, I.; Mucus glycoproteins from normal human tracheobronchial secretion. Biochem. J., 265: 179, 1990.

    PubMed  CAS  Google Scholar 

  35. Rose, M.C.: Characterization of human tracheobronchial mucin glycoproteins. Meth. Enzymol., 179: 3, 1989.

    Article  PubMed  CAS  Google Scholar 

  36. Dekker, J., Strous, G.J.: Covalent oligomerization of rat gastric mucin occurs in the rough endoplasmic reticulum, in N-glycosylation-dependent and precedes initial O-glycosylation. J. Biol. Chem., 265: 18116, 1990.

    PubMed  CAS  Google Scholar 

  37. Ederer, G.M., Matsen, J.M.: Colonization and infection with Pseudomonas cepacia. J. Infect. Dis., 125: 613, 1972.

    Article  PubMed  CAS  Google Scholar 

  38. Sajjan, U.S., Corey, M., Karmali, M.A., Forstner, J.F.: Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. J. Clin. Invest., 89: 648, 1992.

    Article  PubMed  CAS  Google Scholar 

  39. Wanke, C.A., Cronan, S., Goss, C., Chadee, K., Guerrant, R.L.: Characterization of binding Escherichia coli strains which are enteropathogens to small-bowel mucin. Infect. Immun., 58: 794, 1990.

    PubMed  CAS  Google Scholar 

  40. Forstner, J.F., Wesley, A., Mantle, M., Kopelman, H., Man, D., Forstner, G.: Abnormal fluid: Nominated but not yet elected. J. Pediatr. Gastroenterol. Nutr., 3(Suppl): S67, 1994.

    Article  Google Scholar 

  41. Podolsky, D.K., Fournier, D.A.: Alterations in mucosal content of colonic glycoconjugates in inflammatory bowel disease by monoclonal antibodies. Gastroenterology, 95: 379, 1988.

    PubMed  CAS  Google Scholar 

  42. Drumm, B., Roberton, A.M., Sherman, P.M.: Inhibition of attachment of Escherichia coli RDEC-1 to intestinal microvillus membranes by rabbit ileal fluid and mucin in vitro. Infect. Immun., 56: 2437, 1988.

    PubMed  CAS  Google Scholar 

  43. Mantle, M., Basaraba, L., Peacock, S.C., Gall, D.G.: Binding of Yersinia enterolitica to rabbit intestinal brush border membranes, fluid, and mucin. Infect. Immun., 57: 3292, 1989.

    PubMed  CAS  Google Scholar 

  44. Mantle, M., Husar, S.D.: Adhesion of Yersinia enterocolitica to purified rabbit and human intestinal mucin. Infect. Immun., 61: 2340, 1993.

    PubMed  CAS  Google Scholar 

  45. Duncan, J.L.: Differential effects of Tamm-Horsfall protein on adherence of Escherichia coli to transitional epithelial cells. J. Infect. Dis., 158: 1379, 1988.

    Article  PubMed  CAS  Google Scholar 

  46. Venegas, M.F., Navas, E.L., Gaffney, R., Duncan, J.L., Anderson, B.E., Schaeffer, A.J.: Binding of type 1 piliated Escherichia coli to vaginal mucus. Infect. Immun. 63: 416, 1995.

    PubMed  CAS  Google Scholar 

  47. Gaffney, R.A., Venegas, M.F., Kanerva, C., Navas, E.L., Anderson, B.E., Duncan, J.L., Schaeffer, A.J.: Effect of vaginal fluid on adherence of type 1 piliated Escherichia coli to epithelial cells. J. Infect. Dis., 172: 1528, 1995.

    Article  PubMed  CAS  Google Scholar 

  48. Schaeffer, A. J., Navas, E.L., Venegas, M.F., Anderson, B.E., Kanerva, C., Chmiel, J.S., Duncan, J.L.: Variation of blood group antigen expression on epithelial cells and mucus in secretor and nonsecretor women. J. Urol., 152: 859, 1994.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Northwestern University Medical School, 303 East Chicago Avenue, Tarry 11-715, Chicago, Illinois, 60611-3008, USA

    Anthony J. Schaeffer, Nithya Rajan, E. Thorburn Wright, James L. Duncan & Byron E. Anderson

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  1. Anthony J. Schaeffer
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  2. Nithya Rajan
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  3. E. Thorburn Wright
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  4. James L. Duncan
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  5. Byron E. Anderson
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Editors and Affiliations

  1. Department of Urology, University of California, San Francisco, USA

    Laurence S. Baskin  & Simon W. Hayward  & 

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Schaeffer, A.J., Rajan, N., Wright, E.T., Duncan, J.L., Anderson, B.E. (1999). Role of Vaginal Colonization in Urinary Tract Infections (UTIs). In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_26

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  • DOI: https://doi.org/10.1007/978-1-4615-4737-2_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7147-2

  • Online ISBN: 978-1-4615-4737-2

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