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Urothelial Tissue Regulation

Unraveling the Role of the Stroma

  • Chapter
Advances in Bladder Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 462))

Abstract

The internal and external surfaces of the body are lined by epithelial tissues. As such, epithelial tissues have a common role in forming the interface with the external environment. This commonality of function is apparent in the basic polarized structure of epithelia, with the apical cell surface abutting onto a luminal or external free space and the basolateral surface anchored to a basement membrane with an underlying mesenchymal stroma. A number of commonly-expressed epithelial gene products play a role in epithelial tissue organization and can be considered as markers of epithelial cell lineage. Such markers include the cytokeratins, E-cadherin and various junctional proteins. Different epithelial tissues also show a diverse range of highly specialized functions which are reflected in their tissue organization, cellular morphology and the expression of specific gene products.

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Authors and Affiliations

  1. Imperial Cancer Research Fund Cancer Medicine Research Unit, St James’s University Hospital, Leeds, LS9 7TF, UK

    Jennifer Southgate, Peter J. Selby & Ludwik K. Trejdosiewicz

  2. Department of Pathology, St James’s University Hospital, Leeds, LS9 7TF, UK

    Patricia Harnden

  3. Department of Paediatric Urology, St James’s University Hospital, Leeds, LS9 7TF, UK

    David F. M. Thomas

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  3. Peter J. Selby
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  5. Ludwik K. Trejdosiewicz
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  1. Department of Urology, University of California, San Francisco, USA

    Laurence S. Baskin  & Simon W. Hayward  & 

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Southgate, J., Harnden, P., Selby, P.J., Thomas, D.F.M., Trejdosiewicz, L.K. (1999). Urothelial Tissue Regulation. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_2

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  • DOI: https://doi.org/10.1007/978-1-4615-4737-2_2

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