Skip to main content
SpringerLink
Log in

Cyclooxygenase-2

A Key Regulator of Bladder Prostaglandin Formation

  • Chapter
Advances in Bladder Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 462))

Abstract

Since Felix Hoffman first synthesized acetylsalicylic acid (aspirin) in 1897, prostaglandin synthesis inhibitors have been widely used as effective anti-inflammatory, analgesic and anti-pyretic agents. Much of our present understanding regarding prostaglandins (PGs) in fact derives from observing the effects of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) which inhibit PG synthesis by interfering with one of the rate-limiting enzymes, cyclooxygenase. In addition to regulating immune responses, pain, and fever, PGs are now implicated as playing an important role as autocrine/paracrine modulators of cellular responses such as mitogenesis and apoptosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gilmore, N. J., and J. R. Vane.: Hormones released into the circulation when the urinary bladder of the anesthetized dog is distended. Clin. Sci., 41: 69, 1971.

    PubMed  CAS  Google Scholar 

  2. Mikhailidis, D. P., J. Y. Jeremy, and P. Dandona.: Urinary bladder prostanoids — their synthesis, function and possible role in the pathogenesis and treatment of disease. J. Urol., 137: 577. 1987.

    PubMed  CAS  Google Scholar 

  3. Bultitude, M. I., N. H. Hills, and K. E. L. Shuttleworth.: Clinical and experimental studies on the action of prostaglandins and their synthesis inhibitors on detrusor muscle in vivo and in vitro. Br. J. Urol., 48: 631, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Maggi, C. A.: Prostanoids as local modulators of reflex micturition. Pharmacol. Res., 25: 13, 1992.

    Article  PubMed  CAS  Google Scholar 

  5. Smith, W. L., R. M. Garavito, and D. L. De Witt.: Prostaglandin endoperoxide H synthases (cyclooxygenases) -1 and -2. J. Biol. Chem., 271: 33157, 1996.

    Article  PubMed  CAS  Google Scholar 

  6. Giuliani, S., P. Santicioli, M. Tramontana, P. Geppetti, and C. A. Maggi.: Peptide N-formyl-methionylleucyl-phenylalanine (FMLP) activates capsaicin-sensitive afferents in guinea pig atria and urinary bladder. Br. J. Pharmacol., 102: 730, 1991.

    Article  PubMed  CAS  Google Scholar 

  7. Khalaf, I. M., J. G. Lehoux, L. A. Elshawarby, and M. M. Elhilali.: Release of prostaglandins into the pelvic venous blood of dogs in response to vesical distention and pelvic nerve stimulation. Invest. Urol., 17: 244, 1979.

    PubMed  CAS  Google Scholar 

  8. Downie, J. W., and M. Karmazyn.: Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusor muscle. J Pharmacol Exp. Ther., 230: 445, 1984.

    PubMed  CAS  Google Scholar 

  9. Leslie, C. A., A. J. Pavlakis, J. S. Wheeler, M. B. Siroky, and R. J. Krane.: Release of arachidonate cascade products by the rat urinary bladder: neurophysiological significance? J. Urol., 132: 376, 1984.

    PubMed  CAS  Google Scholar 

  10. Brown, W. W., Z. T. V., and B. B. Davis.: Prostaglandin E2 production by rabbit urinary bladder. Am. J. Physiol., 239: F452, 1980.

    PubMed  CAS  Google Scholar 

  11. Maggi, C. A., S. Giuliani, R. Patacchini, B. Conte, M. Furio, P. Santicioli, P. Meli, L. Gragnani, and A. Meli.: The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur. J. Pharmacol., 152: 273, 1988.

    Article  PubMed  CAS  Google Scholar 

  12. Maggi, C. A., S. Giuliani, B. Conte, M. Furio, P. Santicioli, P. Meli, L. Gragnani, and A. Meli.: Prostanoids modulate reflex micturition by acting through capsaicin-sensitive afferents. Eur. J. Pharmacol., 145: 105, 1988.

    Article  PubMed  CAS  Google Scholar 

  13. Cardozo, L. D., and S. L. Stanton.: Comparison between bromocriptine and indomethacin in the treatment of detrusor instability. J. Urol., 123: 399, 1980.

    PubMed  CAS  Google Scholar 

  14. Maggi, C. A., P. Santicioli, M. Furio, and A. Meli.: The effect of cyclooxygenase inhibitors on the low filling rate cystometrogram in urethane anesthetized rats. J. Urol., 134: 800, 1985.

    PubMed  CAS  Google Scholar 

  15. Gold, M. S., D. B. Reichling, M. J. Shuster, and J. D. Levine.: Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc. Natl. Acad. Sci. USA., 93: 1108, 1996.

    Article  PubMed  CAS  Google Scholar 

  16. Maggi, C. A., F. Santicioli, and A. Meli.: Evidence for the involvement of a capsaicin-sensitive innervation in the afferent branch of micturition reflex in rats. Acta Physiologica Hungarica., 69: 425, 1987.

    PubMed  CAS  Google Scholar 

  17. Wallace, J. L., and D. N. Granger.: The cellular and molecular basis of gastric mucosal defense. F.A.S.E.B. J., 10: 731, 1996.

    CAS  Google Scholar 

  18. Mohiuddin, J., H. G. Prentice, S. Schey, H. Blacklock, and P. Dandona.: Successful treatment of cyclophosphamide-induced hemorrhagic cystitis with intravesical infusion of prostaglandin E2. Ann. Int. Med., 101: 142, 1984.

    PubMed  CAS  Google Scholar 

  19. El-Gendi, M. A., S. H. Nassar, M. D. Toppozada, and F. Abdel-Raheem.: Pharmacotherapeutics of prostaglandin E2 and 15(S)-15-methyl prostaglandin F2a in chronic schistosomal bladder ulcer: a clinicoendoscopic study. Prostaglandins, 24: 97, 1982.

    PubMed  CAS  Google Scholar 

  20. Green, R. M., V. I. MacAndrew, and M. R. Lloyd.: Stimulation of glycosaminoglycan synthesis by cyclic AMP. Biochem. Biophys. Res. Commun., 107: 232, 1982.

    Article  Google Scholar 

  21. Simmons, D. L., D. B. Levy, Y. Yannoni, and R. L. Erikson.: Identification of a phorbol ester repressible vsrc-inducible gene. Proc. Natl. Acad. Sci. USA., 86: 1178, 1989.

    Article  PubMed  CAS  Google Scholar 

  22. Yokoyama, C., and T. Tanabe.: Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem. Biophys. Res. Commun., 165: 888, 1989.

    Article  PubMed  CAS  Google Scholar 

  23. Kosaka, T., A. Miyata, H. Ihara, H. S., T. Sugimoto, O. Takeda, E. Takahashi, and T. Tanabe.: Characterization of the human gene (PTGS2) encoding prostaglandin endoperoxide synthase 2. Eur. J. Biochem., 221: 889, 1994.

    Article  PubMed  CAS  Google Scholar 

  24. Smith, W. L.: Pharmacology of prostaglandin endoperoxide synthase isoenzyme 1 and 2. Ann. N.Y. Acad. Sci., 714: 136, 1994.

    Article  PubMed  CAS  Google Scholar 

  25. Seibert, K., J. L. Masferrer, P. Needleman, and D. Salvemini.: Pharmacological manipulation of cyclo-oxy-genase-2 in the inflamed hydronephrotic kidney. Br. J. Pharmacol., 117: 1016, 1996.

    Article  PubMed  CAS  Google Scholar 

  26. Park, J. M., T. Yang, L. J. Arend, S. A. M., J. B. Schnermann, and J. B. Briggs.: Cyclooxygenase 2 is expressed in bladder during fetal development and stimulated by outlet obstruction. Am. J. Physiol., 273: F538, 1997.

    PubMed  CAS  Google Scholar 

  27. Morham, S. G., R. Langenbach, C. D. Loftin, H. F. Tiano, N. Vouloumanos, J. C. Jennette, J. F. Mahler, K. D. Kluckman, A. Ledford, C. A. Lee, and O. Simithies.: Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell, 83: 473, 1995.

    Article  PubMed  CAS  Google Scholar 

  28. Dinchuk, J. E., B. D. Car, R. J. Focht, J. J. Johnston, B. D. Jaffe, M. B. Covington, N. R. Contel, V. M. Eng, R. J. Collins, P. M. Czerniak, S. A. Gorry, and J. M. Trzaskos.: Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature, 378: 406, 1995.

    Article  PubMed  CAS  Google Scholar 

  29. Herschman, H. R.: Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem., 60: 281, 1991.

    Article  PubMed  CAS  Google Scholar 

  30. Pritchard, K. A., M. K. O’Bannon, J. M. Miano, N. Vlasic, U. G. Bhatia, D. A. Young, and M. B. Sterner-man.: Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J. Biol. Chem., 269: 8504, 1994.

    PubMed  CAS  Google Scholar 

  31. Akai, Y., T. Homma, K. D. Burns, T. Yasuda, K. F. Badr, and R. C. Harris.: Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am. J. Physiol., 267: C482, 1994.

    PubMed  CAS  Google Scholar 

  32. Yamamoto, M., S. C. Harm, W. A. Grasser, and M. A. Thiede.: Parathyroid hormone related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc. Natl. Acad. Sci. USA., 89: 5326, 1992.

    Article  PubMed  CAS  Google Scholar 

  33. Pavlakis, A. J., M. B. Siroky, C. A. Leslie, and R. J. Krane.: Prostaglandins in lower urinary tract. Neurourol. Urodyn., 2: 105, 1983.

    Article  CAS  Google Scholar 

  34. Seibert, K., J. Masferrer, Y. Zhang, K. Leahy, S. Häuser, J. Gierse, C. Koboldt, G. Anderson, M. Bremer, S. Gregory, and et al.: Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase. Adv. Prostagl. Thromb. Leukotr. Res., 23: 125, 1995.

    CAS  Google Scholar 

  35. Williams, C. S., and R. N. DuBois.: Prostaglandin endoperoxide synthase: why two isoforms? Am. J. Physiol., 270: G393, 1996.

    PubMed  CAS  Google Scholar 

  36. Morita, I., M. Schindler, M. K. Regier, J. C. Otto, T. Hori, D. L. DeWitt, and W. L. Smith.: Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem., 270: 10902, 1995.

    Article  PubMed  CAS  Google Scholar 

  37. Kargman, S., G. O’Neill, P. Vickers, J. Evans, J. Mancini, and S. Jothy.: Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res., 55: 2556, 1995.

    PubMed  CAS  Google Scholar 

  38. Eberhart, C. B., R. J. Coffey, A. Radhika, F. M. Giardiello, S. Ferrenbach, and R. N. DuBois.: Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 107: 1183, 1994.

    PubMed  CAS  Google Scholar 

  39. Tsujii, M., and R. N. DuBois.: Alteration in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83: 493, 1995.

    Article  PubMed  CAS  Google Scholar 

  40. Tsujii, M., S. Kawano, and R. N. DuBois.: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc. Natl. Acad. Sci. USA., 94: 3336, 1997.

    Article  PubMed  CAS  Google Scholar 

  41. Wilborn, J., L. J. Crofford, M. D. Burdick, S. L. Kunkel, R. M. Strieter, and M. Peters-Golden.: Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J. Clin. Invest., 95: 1861, 1995.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    John M. Park

  2. Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Jürgen B. Schnermann

  3. National Institutes of Health, NIDDK, Bethesda, Maryland, USA

    Josephine P. Briggs

Authors
  1. John M. Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jürgen B. Schnermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Josephine P. Briggs
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Urology, University of California, San Francisco, USA

    Laurence S. Baskin  & Simon W. Hayward  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Park, J.M., Schnermann, J.B., Briggs, J.P. (1999). Cyclooxygenase-2. In: Baskin, L.S., Hayward, S.W. (eds) Advances in Bladder Research. Advances in Experimental Medicine and Biology, vol 462. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4737-2_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4737-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7147-2

  • Online ISBN: 978-1-4615-4737-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation