Abstract
Dihydrodiol dehydrogenase (DD) [EC 1. 3. 1. 20] catalyzes the NADP+-linked oxidation of /trans-dihydrodiols of polycyclic aromatic hydrocarbons to corresponding catechols, and controls the formation of both their carcinogenic dihydrodiol epoxides (Oesch, et al.,, 1984) and cytotoxic o-quinones through autoxidation of the catechol metabolites (Flowers, et al.,., 1996). In addition, DD in mammalian liver is implicated in the metabolism of xenobiotic carbonyl compounds, steroids and prostaglandins because of its broad substrate specificity (Penning, et al.,, 1986; Hara, et al.,, 1986; Ohara, et al.,, 1994; 1995).
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Shiraishi, H., Matsuura, K., Kume, T., Hara, A. (1999). Expression of mRNAs for Dihydrodiol Dehydrogenase Isoforms in Human Tissues. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_68
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DOI: https://doi.org/10.1007/978-1-4615-4735-8_68
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