Abstract
Ethanol is primarily metabolized by oxidation and the three enzymatic systems currently considered to contribute to alcohol metabolism are alcohol dehydrogenase (ADH), cytochrome P-450 and peroxisomal catalase (Lieber et al., 1970; Thurman et al., 1972). It is generally accepted that in many species alcohol oxidation is primarily catalyzed by ADH and that accounts for over 60% of ethanol metabolism. The contribution of other metabolic pathways to ethanol metabolism has been estimated by utilizing specific inhibitors (in particular 4-methylpyrazole, an inhibitor of ADH).
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Domenicotti, C. et al. (1999). Primary Role of Alcohol Dehydrogenase Pathway in Acute Ethanol-Induced Impairment of Protein Kinase C-Dependent Signaling System. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_39
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DOI: https://doi.org/10.1007/978-1-4615-4735-8_39
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