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Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling

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Enzymology and Molecular Biology of Carbonyl Metabolism 7

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 463))

Abstract

Vitamin A (retinol) must be metabolized to retinoic acid in order to fulfill its roles in vertebrate growth and development (Blaner and Olson, 1994; Maden, 1994; Hofmann and Eichele, 1994). Retinoic acid mediates retinoid signaling by binding to and modulating the transcriptional regulatory properties of nuclear retinoic acid receptors (Kastner et al, 1994; Mangelsdorf et al, 1994). Retinoic acid reporter assays of individual mouse embryos indicate that retinoic acid is undetectable during the initial stage of gastrulation, but that it is easily detectable later in gastrulation and neurulation (Rossant et al, 1991; Ang et al, 1996a). Retinoic acid receptors are expressed prior to detection of retinoic acid in mouse embryos (Dollé et al, 1990; Ruberte et al, 1991; Ang and Duester, 1997), indicating that a major factor governing retinoid signaling is the induction of endogenous retinoic acid synthesis during embryogenesis. To unravel this layer of biological control in the retinoid signaling pathway an understanding of the enzymes involved in retinoic acid synthesis is needed.

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Authors and Affiliations

  1. Gene Regulation Program, Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, California, 92037, USA

    Gregg Duester

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  1. Gregg Duester
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Editors and Affiliations

  1. Purdue University, West Lafayette, Indiana, USA

    Henry Weiner

  2. Philipps University of Marburg, Marburg, Germany

    Edmund Maser

  3. Indiana University School of Medicine, Indianapolis, Indiana, USA

    David W. Crabb

  4. University of South Dakota School of Medicine, Vermillion, South Dakota, USA

    Ronald Lindahl

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Duester, G. (1999). Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_38

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  • DOI: https://doi.org/10.1007/978-1-4615-4735-8_38

  • Publisher Name: Springer, Boston, MA

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