Abstract
Recent evidence suggests that in addition to their well studied toxic effects, reactive oxygen species (ROS) are also essential mediators of cell growth, differentiation and apoptosis (Sen and Packer, 1996; Lander, 1997). Nonetheless, the mechanisms by which ROS alter cell function remain obscure. Since free radicals derived from oxygen are generally short-lived and react predominantly at their site of generation, it is likely that their metabolic as well as the toxic effects are mediated, in part, by their metastable products, particularly those derived from the peroxidation of membrane lipids. Peroxidation of unsaturated fatty acids generates a variety of metastable compounds of which aldehydes are the most abundant end-products (Esterbauer et al., 1991; Witz, 1983). In comparison only minor amounts of ketones, epoxides, hydrocarbons, alcohols and acids are formed (Grosch, 1987). Therefore, in cellular systems, aldehyde burden may be an important consequence of lipid peroxidation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bhatnagar, A. (1995) Electrophysiological effects of 4-hydroxynonenal, an aldehydic product of lipid peroxida-tion, on isolated rat ventricular myocytes. Cire. Res. 76, 293–304.
Bhatnagar, A. (1997) Contribution of ATP to oxidative stress-induced changes in the action potential of isolated cardiac myocytes. Am. J. Physiol. 272, H1598–H1608.
Bhatnagar, A. and Srivastava, S. K. (1992) Aldose reductase: Congenial and injurious profiles of an enigmatic enzyme. Biochem. Med. Metabol. Biol. 48, 91–121.
Chandra, A. and Srivastava, S. K. (1997) A synthesis of 4-hydroxy-2-trans-nonenal and 4-(3H) 4-hydroxy-2-trans-nonenal. Lipids 32, 779–782.
Esterbauer, H., Schaur, R. J. and Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonalde-hyde and related aldehydes. Free Radic Biol Med. 11, 81–128.
Grosch, W. (1987) Reactions of hydroperoxides-products of low molecular weight. In Autoxidation of Unsatu-rated Lipids. (H. W.-S. Chan Ed. ) Academic Press, London, pp 95–139.
Lander, H. M. (1997) An essential role of free radicals and derived species in signal transduction. FASEB J. 11, 118–124.
Lucas, D. T. and Szweda, L. I. (1998) Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction. Proc. Natl. Acad. Sci. 95, 510–514.
Nath, R. G. and Chung, F-L. (1994) Detectionof exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans. Proc. Natl. Acad. Sci. 91, 7491–7495.
Sayre, L. M., Zelasko, D. A., Harris, P. L., Perry, G., Salomon, R. G. and Smith, M. A. (1997) 4-Hydroxynonenal-de-rived advanced lipid peroxidation end products are increased in Alzheimer’s disease. J. Neurochem. 68, 2092–2097.
Sen, C. K. and Packer, L. (1996) Antioxidant and redox regulation of gene transcription. FASEB J. 10, 709–720.
Srivastava, S., Chandra, A., Ansari, N. H., Srivastava, S. K. and Bhatnagar, A. (1998a) Identification of cardiac oxi-doreductase(s) involved in the metabolism of the lipid peroxidation derived aldehyde-4-hydoxynonenal. Biochem. J. 329, 469–475.
Srivastava, S., Chandra, A., Wang, L.-F., Seifert, W. E., DaGue, B. B., Ansari, N. H., Srivastava, S. K. and Bhatnagar, A. (1998b) Metabolism of the lipid peroxidation product, 4-hydoxy-trans-2-nonenal, in isolated perfused rat heart. J. Biol. Chem. 273, 10893–10900
Witz, G. (1989) Biological interactions of alpha, beta-unsaturated aldehydes. Free Radic. Biol. Med. 7, 333–49.
Yla-Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S., Witztum J. L. and Steinberg D. (1989) Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84, 1086–1095.
Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R. and Mizuno, Y. (1996) Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc. Natl. Acad. Sci. 93, 2696–2701.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bhatnagar, A., Srivastava, S., Wang, LF., Chandra, A., Ansari, N.H., Srivastava, S.K. (1999). Cardiac Metabolism of Enals. In: Weiner, H., Maser, E., Crabb, D.W., Lindahl, R. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 7. Advances in Experimental Medicine and Biology, vol 463. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4735-8_27
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4735-8_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7146-5
Online ISBN: 978-1-4615-4735-8
eBook Packages: Springer Book Archive