Molecular Farming of Industrial Proteins from Transgenic Maize

  • Elizabeth E. Hood
  • Ann Kusnadi
  • Zivko Nikolov
  • John A. Howard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 464)


Recombinant egg white avidin and bacterial B-glucuronidase (GUS) from transgenic maize have been commercially produced. High levels of expression were obtained in seed by employing the ubiquitin promoter from maize. The recombinant proteins had activities that were indistinguishable from their native counterparts. We have illustrated that downstream activities in the production of these recombinant proteins, such as stabilizing the germplasm and processing for purification, were accomplished without any major obstacles. Avidin (A8706) and GUS (G2035) are currently marketed by Sigma Chemical Co.


Transgenic Plant Maize Seed Transgenic Maize Ubiquitin Promoter Molecular Farming 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Elizabeth E. Hood
    • 3
    • 4
  • Ann Kusnadi
    • 1
  • Zivko Nikolov
    • 1
    • 2
  • John A. Howard
    • 3
  1. 1.Department of Food Science and Human NutritionIowa State UniversityAmesUSA
  2. 2.Department of Agricultural and Biosystems EngineeringIowa State UniversityAmesUSA
  3. 3.Iowa State UniversityAmesUSA
  4. 4.ProdiGene, Inc.College StationUSA

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