Abstract
Nitric oxide (NO) plays an important role in the regulation of the cerebral blood flow (CBF) (for review see: Faraci and Heistad, 1998). Inhibition of the L-arginine—NO pathway results in cerebral vasoconstriction and reduction of the CBF, indicating that the basal release of NO provides a resting relaxant tone in the cerebrovascular bed (for review see: Iadecola et al., 1994). This effect of basal NO production has generally been regarded as a direct relaxant action on the smooth muscle. The possibility that NO may regulate the resting cerebrovascular tone by modulation of the prostanoid synthesis has not been investigated to date.
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Benyó, Z., Görlach, C., Wahl, M. (1999). Interaction between Nitric Oxide and Thromboxane A2 in the Regulation of the Resting Cerebrovascular Tone. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_45
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_45
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