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Redox States of Cerebral Tissues of Rats Substituted by the Liposome-Encapsulated Hemoglobin

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Oxygen Transport to Tissue XXI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 471))

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Abstract

Many kinds of artificial blood that have the ability to transport oxygen into tissues have been proposed. Hemoglobin vesicles, in particular, have advantages over other ones because of their longer half-lives and lower viscosity in circulation.10,11,12 Neo Red Cells (NRC) is the liposome-encapsulated human hemoglobin, and the P50O2 of NRC is changeable in the range of 13–60 Torr in accord with the variation in the addition of inositolhexaphosphate (IHP) as an allosteric effector.8

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References

  1. Cooper CE and Springett R (1997) Measurement of cytochrome oxidase and mitochondrial energetics by near-infrared spectroscopy. Phil Trans. R. Soc. Lond. B 352:669–676.

    Article  CAS  Google Scholar 

  2. Delpy DT and Cope M (1997) Quantification in tissue near-infrared spectroscopy. Phil. Trans. R. Soc. Lond. B 352:649–659.

    Article  CAS  Google Scholar 

  3. Ferrari M, Williams MA, Wilson DA, Thakor NV, Traystman RJ, and Hanley DF (1995) Cat brain cytochrome-c oxidase redox changes induced by hypoxia after blood-fluorocarbon exchange transfusion. Am. I Physiol 269 (Heart Cira Physiol. 38):H417–424.

    CAS  Google Scholar 

  4. Hazeki O and Tamura M (1988) Quantitative analysis of hemoglobin oxygenation state of rat brain in situ by near-infrared spectrophotometry. J. Appl Physiol. 64(2):796–802.

    PubMed  CAS  Google Scholar 

  5. Hazeki O and Tamura M (1989) Near infrared quadruple wavelength spectrophotometry of the rat head. Adv. Exp. Med. Biol. 248:63–69.

    Article  PubMed  CAS  Google Scholar 

  6. Hoshi Y and Tamura M (1993) Dynamic multichannel near-infrared optical imaging of human brain activity. J. Appl. Physiol. 75(4): 1842–1846.

    PubMed  CAS  Google Scholar 

  7. Hoshi Y, Hazeki O, Kakihana Y, and Tamura M (1997) Redox behavior of cytochrome oxidase in the rat brain measured by near-infrared spectroscopy. J. Appl. Physiol. 83(6): 1842–1848.

    PubMed  CAS  Google Scholar 

  8. Ogata Y, Goto H, Sakaguchi K, Suzuki M, Ohsaki K, Suzuki K, Saniabadi AR, Kamitani T, and Takahashi A (1994) Characteristics of Neo Red Cells, their function and safety: in vivo studies. Art. Cells, Blood Subs., and Immob., Biotech. 22(3):875–881.

    Article  CAS  Google Scholar 

  9. Rudolph AS, Sulpizio A, Hieble P, Macdonald V, Chavez M, and Feuerstein G (1997) Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. J. Appl. Physiol. 82(6): 1826–1835.

    PubMed  CAS  Google Scholar 

  10. Rudolph AS (1988) The freeze-dried preservation of liposome encapsulated hemoglobin: a potential blood substitute. Cryobiology 25:277–284.

    Article  PubMed  CAS  Google Scholar 

  11. Takahashi A (1995) Characterization of Neo Red Cells (NRCs), their function and safety in vivo tests. Art. Cells, Blood Subs., and Immob., Biotech. 23(3):347–354.

    Article  CAS  Google Scholar 

  12. Usuba A, Motoki R, Ogata Y, Suzuki K, and Kamitani T (1995) Effect and safety of liposome-encapsulated hemoglobin Neo Red Cells (NRCs) as a perfusate for total cardiopulmonary bypass. Art. Cells, Blood Subs., and Immob., Biotech. 23(3):337–346.

    Article  CAS  Google Scholar 

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© 1999 Springer Science+Business Media New York

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Sakanoue, J., Tamura, M., Nakai, K., Sakuma, I., Kitabatake, A. (1999). Redox States of Cerebral Tissues of Rats Substituted by the Liposome-Encapsulated Hemoglobin. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_4

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  • DOI: https://doi.org/10.1007/978-1-4615-4717-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7137-3

  • Online ISBN: 978-1-4615-4717-4

  • eBook Packages: Springer Book Archive

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