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Critical Capillary PO2 and the Role of Lactate Production in Oxyhemoglobin Dissociation during Exercise

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 471))

Abstract

Lactate increase during exercise takes place above a certain metabolic rate varying with fitness and disease (Wasserman, 1994). The metabolic rate (Vo2) above which lactate starts to increase is thought to be that at which energy (ATP) from anaerobic glycolysis supplements the energy generated from aerobic metabolism. The onset of the anaerobic production of ATP should therefore also be the onset of net lactate production by working muscle during exercise.

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References

  • Chance, B, G Mauriello, and XM Aubert. ADP arrival at muscle mitochondria following a twitch. In: Muscle As A Tissue, edited by K Rodahl and SM Horvath. New York: McGraw-Hill, 1962, pp. 128–145.

    Google Scholar 

  • Drexler, H, V Reide, T Munzel, H Konig, E Funke, and H Just. Alteration of Skeletal Muscle in Chronic Heart Failure. Circulation 85:1751–1759, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Gayeski, TEJ and CR Honig. Intracellular PO2 in long axis of individual fibers in working dog gracilis muscle. Am.J.Physiol. 254:H1179–H1186, 1988.

    Google Scholar 

  • Koike, A, K Wasserman, K Taniguichi, M Hiroe, and F Marumo. Critical capillary oxygen partial pressure and lactate threshold in patients with cardiovascular disease. J. Am. Coll. Cardiol. 23:1644–1650, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Koike, A, D Weiler-Ravell, DK McKenzie, S Zanconato, and K Wasserman. Evidence that the metabolic acidosis threshold is the anaerobic threshold. J Appl. Physiol. 68:2521–2526, 1990.

    PubMed  CAS  Google Scholar 

  • Roughton, FJW. Transport of oxygen and carbon dioxide. In: Handbook of Physiology, 1964, pp. 767-825.

    Google Scholar 

  • Severinghaus, JW. Simple, accurate equations for human blood O2 dissociation computations. J. Appl. Physiol. 46:599–603, 1979.

    PubMed  CAS  Google Scholar 

  • Stringer, W, K Wasserman, R Casaburi, J Porszasz, K Maehara, and W French. Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise. J. Appl. Physiol. 76:1462–1467, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, MJ, HJ Green, and FR Cobb. Altered skeletal muscle metabolic response to exercise in chronic heart failure: relation to skeletal muscle aerobic enzyme activity. Circulation 84:1597–1607, 1991.

    Article  PubMed  CAS  Google Scholar 

  • Vogel, JA and MA Gleser. Effect of carbon monoxide on oxygen transport during exercise. J. Appl. Physiol. 32:234–239, 1972.

    PubMed  CAS  Google Scholar 

  • Wasserman, K. Coupling of external to cellular respiration during exercise: the wisdom of the body revisited. Am. J. Physiol. 266:E519–E539, 1994.

    PubMed  CAS  Google Scholar 

  • Wasserman, K and W Stringer. Critical capillary PO2, net lactate production, and oxyhemoglobin dissociation: Effects on exercise gas exchange. In: Exercise Gas Exchange in Heart Disease, edited by K Wasserman. Armonk, NY: Futura Publishing Company, Inc., 1998, pp. 157–181.

    Google Scholar 

  • Wittenberg, BA and JB Wittenberg. Transport of oxygen in muscle. Ann. Rev. Physiol. 51:857–878, 1989.

    Article  CAS  Google Scholar 

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© 1999 Springer Science+Business Media New York

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Wasserman, K. (1999). Critical Capillary PO2 and the Role of Lactate Production in Oxyhemoglobin Dissociation during Exercise. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_39

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  • DOI: https://doi.org/10.1007/978-1-4615-4717-4_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7137-3

  • Online ISBN: 978-1-4615-4717-4

  • eBook Packages: Springer Book Archive

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