Skip to main content

Cerebral Blood Volume Responses to Acute PaCO2 Changes in Humans, Assessed with Near Infrared Spectroscopy

  • Chapter
Oxygen Transport to Tissue XXI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 471))

Abstract

Near Infrared Spectroscopy (NIRS) can be used to measure cerebral blood volume (CBV), and its reactivity to changes in PaCO2. NIRS is a promising technique, which offers continuous measurements of CBV at bedside and is relatively cheap. Moreover, invasiveness is not necessary, which makes NIRS a very interesting tool for clinical use.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Berne RM and Levy MN (1998) Special circulations. In: Physiology. (Berne RM and Levy MN, Eds) Mosby, Inc. St. Louis, pp. 478–501.

    Google Scholar 

  • Brun NC and Greisen G (1994) Cerebrovascular responses to carbon dioxide as detected by near-infrared spe-ctrophotometry: comparison of three different measures. Ped Res 36(l):20–24.

    CAS  Google Scholar 

  • Edvinsson L, MacKenzie ET, and McCulloch J (1993) Fundamental responses of the cerebral circulation. From: Cerebral blood flow and metabolism, Raven Press, New York, pp. 553–580.

    Google Scholar 

  • Elwell C, Cope M, Edwards D, Wyatt J, Delpy D, and Reynolds EO (1994) Quantification of adult cerebral hemodynamics by near infrared spectroscopy. J Appl Physiol 77:2753–2760.

    CAS  PubMed  Google Scholar 

  • Grubb RL, Raichle ME, Eichling JO, and Ter-Pogossian MM (1974) The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5:630–639.

    Article  PubMed  Google Scholar 

  • Harris DNF and Bailey SM (1993) Near infrared spectroscopy in adults. Anaesthesia 48:694–696.

    Article  CAS  PubMed  Google Scholar 

  • Jöbsis FF (1977) Noninvasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198:1264–1267.

    Article  PubMed  Google Scholar 

  • Kety SS and Schmidt CF (1948) The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27:484–492.

    Article  CAS  PubMed  Google Scholar 

  • Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJR, Gibbs JM, Wise RJS, Hatazawa J, Herold S, Beaney RP, Brooks DJ, Spinks T, Rhodes C, Frackowiak RSJ, and Jones T (1990) Cerebral blood flow, blood volume and oxygen utilization; normal values and effect of age. Brain, 113:27–27.

    Article  PubMed  Google Scholar 

  • Mancini DM, Bolinger L, Li H, Kendrick K, and Wilson JR (1994) Validation of near-infrared spectroscopy in man. J Appl Physiol 77(6):2740–2747.

    CAS  PubMed  Google Scholar 

  • Muizelaar JP, Fatouros PP, and Schröder ML (1997) A new method for quantitative regional cerebral blood volume measurements using computed tomography. Stroke 28(10):1998–2005.

    Article  CAS  PubMed  Google Scholar 

  • Newton CRJC, Wilson DA, Gunnoe E, Wagner B, Cope M, and Traystman RJ (1997) Measurements of cerebral blood flow in dogs with near infrared spectroscopy in the reflectance mode is invalid. J Cerebr Blood Flow Metab 17:695–703.

    CAS  Google Scholar 

  • Østergaard L, Smith DF, Verstergaard-Poulsen P, Hansen SB, Gee AD, Gjedde A, and Gyldensted C (1998) Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: Comparison with positron emission tomography values. J Cereb Blood Flow Metab 18(4):425–432.

    Article  PubMed  Google Scholar 

  • Owen-Reece H, Elwell CE, Harkness W, Goldstone J, Delpy DT, Wyatt JS, and Smith M (1996) Use of near infrared spectroscopy to estimate cerebral blood flow in conscious and anaesthetized adult subjects. Br J Anaesth 76:43–48.

    Article  CAS  PubMed  Google Scholar 

  • Shockley RP and LaManna JC (1988) Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation. Brain Res 454:170–178.

    Article  CAS  PubMed  Google Scholar 

  • Van de Ven MJT, Colier WNJM, Walraven D, Oeseburg B, and Folgering H (1998) Cerebral blood flow in humans measured with near infrared spectroscopy is not reproducible. Adv Exp Med Biol (in press).

    Google Scholar 

  • Van de Ven MJT, Colier WNJM, Walraven D, Oeseburg B, and Folgering H (1998) Reproducibility of cerebral blood volume measurements assessed with near infrared spectroscopy. Abstract ISOTT.

    Google Scholar 

  • Van der Sluijs MC, Colier WNJM, Houston RJF, and Oeseburg B (1997) A new and highly sensitive continuous wave near infrared spectrophotometer with multiple detectors. SPIE 3194:63–72.

    Article  Google Scholar 

  • Van der Zee P, Cope M, Arridge SR, Essenpreis M, Potter LA, Edwards AD, Wyatt JS, McCormick DC, Roth SC, Reynolds EOR, and Delpy DT (1992) Experimentally measured optical pathlengths for the adult head, calf and forearm and the head of the newborn infant as a function of interoptode spacing. Adv Exp Med Biol 316:143–153.

    Article  PubMed  Google Scholar 

  • Wyatt JS, Cope M, and Delpy DT (1990) Quantitation of cerebral blood volume in human infants by near infrared spectroscopy. J Appl Physiol 68(3): 1086–1091.

    CAS  PubMed  Google Scholar 

  • Van Zijl PCM, Eleff SM, Ulatowski JA, Oja JME, Ulug AM, Traystman RJ, and Kauppinen RA (1998) Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 4(2): 159–167.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Science+Business Media New York

About this chapter

Cite this chapter

Van de Ven, M.J.T., Colier, W.N.J.M., Kersten, B.T.P., Oeseburg, B., Folgering, H. (1999). Cerebral Blood Volume Responses to Acute PaCO2 Changes in Humans, Assessed with Near Infrared Spectroscopy. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-4717-4_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7137-3

  • Online ISBN: 978-1-4615-4717-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics