Abstract
We examined the preventive effect of melatonin on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats. In rats injected with CCl4 (1.0 ml/kg body weight), liver injury appeared 6h after the injection and progressed at 24 h. This liver injury progression was prevented by treatment with melatonin (50 or 100mg/kg body weight), which was conducted 6h after CCl4 injection. An increase in liver lipid peroxide content and a decrease in liver reduced glutathione content occurred with the liver injury progression. These changes were prevented by the post-treatment of melatonin (50 or 100mg/kg body weight). These results indicate that melatonin can prevent the progression of CCl4-induced acute liver injury through its antioxidant action.
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Ohta, Y., Kongo, M., Sasaki, E., Nishida, K., Ishiguro, I. (1999). Preventive Effect of Melatonin on the Progression of Carbon Tetrachloride-Induced Acute Liver Injury in Rats. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_42
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_42
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