Abstract
Metabolism of 14C-labeled tryptophan and 3-hydroxyanthranilic acid were administered to early hepatoma patients to evaluate the conversion of these precursors to niacin metabolites and to assess the effect of dietary supplementation with vitamin B-6, riboflavin, thiamin and vitamin C on the extent of conversion. Expired labeled carbon dioxide and urinary excretion of picolinic acid (PA), quinolinic acid (QA), nicotinic acid (NA), N1− methylnicotinamide (N1MeNAm) and N1−methyl-2-pyridone-5-carboxamide (MPCA) were measured by carrier isolations. There were no consistent statistical differences in these conversions before and after vitamin supplementation, suggesting that the patients’ nutrition was adequate and that none of the vitamins were rate-limiting under these conditions.
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References
Hankes, L.V., Brown, R.R., Leklem, J., Schmaeler, M., and Jesseph, J., 1972, Metabolism of C14 labeled enantiomers of tryptophan, kynurenine and hydroxykynurenine in humans with scleroderma, J. Invest. Dermatol. 58:85–95.
Hankes, L.V., De Bruin E., Jansen C.R., Vorster, L., and Schmaeler, ML, 1977, Metabolism of 14C-labelled L-tryptophan, L-kynurenine and hydroxy-kynurenine in miners with scleroderma, South African Medical J. 51:383–390.
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© 1999 Springer Science+Business Media New York
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Hankes, L.V., Schmaeler, M., Jansen, C.R., Brown, R.R. (1999). Vitamin Effects on Tryptophan-Niacin Metabolism in Primary Hepatoma Patients. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_36
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_36
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