Abstract
Prevention of primary pain is a new topic, endowed with social and economic interest. We observed that L-5-HTP can induce a significant decrease of the cropping out of migraine, the commonest primary pain. This finding seems interesting, since it represents the first data in the field and was obtained in a prospective, long-term, placebo controlled study. The result obtained suggests that CNS abnormalities underlying the mechanism of migraine can be changed by L-5-HTP, if the amino acid is administered to subjects who are predisposed to headache.
Address for correspondence: Federigo Sicuteri, Interuniversity Centre of Neurochemistry and Clinical Pharmacology of Idiopathic Headache & Department of Internal Medicine, 18 Viale Pieraccini, 50139 Florence, Italy, Tel: +39 (55) 59.91.86, Fax: +39 (55) 59.75.00, e-mail: sicuteri@iol.it.
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Nicolodi, M., Sicuteri, F. (1999). L-5-Hydroxytryptophan Can Prevent Nociceptive Disorders in Man. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_23
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_23
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