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Brain Tryptophan/Serotonin Perturbations in Metabolic Encephalopathy and the Hazards Involved in the Use of Psychoactive Drugs

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Book cover Tryptophan, Serotonin, and Melatonin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 467))

Abstract

Several combined pathogenetic factors such as hyperammonemia, different brain tryptophan metabolic disturbancies and serotonin physiological/pharmacological alterations not yet defined in all details, will often give rise to the clinical neuropsychiatric condition known as hepatic encephalopathy (HE). Indeed, to this the probable exposure to novel potent CNS-monoamine acting drugs today may put such patients at certain risk for other phar-macodynamic (PD) responses than usually are expected from these “safe” drugs. Moreover, with a compromised liver function in HE, also pharmacokinetic (PK) features for the drugs are likely changed in these patients. Thus, the ultimate clinical outcome by this probable but unknown PD/PK-deviation for such psychoactive drugs when given to HE-patients needs further clarification. Accordingly, delineation of both PD- and PK-effects in experimental HE should shed light on this issue of relevance for monoamine-active drug safety as well as on some further details in the complex tryptophan/monoamine-related patho-physiology that comes into play in HE.

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Authors and Affiliations

  1. Department of Psychiatry, University Hospital, SE-581 85, Linköping, Sweden

    Finn Bengtsson

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  1. Finn Bengtsson
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  1. Department of Psychiatry, University of Göttingen, Göttingen, Germany

    Gerald Huether

  2. Department of Clinical Chemistry, University of Heidelberg, Heidelberg, Germany

    Walter Kochen

  3. Department of Food Chemistry, University of Hamburg, Hamburg, Germany

    Thomas J. Simat

  4. Department of Food Chemistry, University of Hamburg, Hamburg, Germany

    Hans Steinhart

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Bengtsson, F. (1999). Brain Tryptophan/Serotonin Perturbations in Metabolic Encephalopathy and the Hazards Involved in the Use of Psychoactive Drugs. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_20

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  • DOI: https://doi.org/10.1007/978-1-4615-4709-9_20

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