Abstract
Advances in the analysis of tryptophan,—(both in its free form and bound, alone or together with its metabolites),—has been compiled on the basis of the relevant papers published in the last 4-5 years, including author’s experiences associated with the preparation of derivatives and with any of those conditions arising from the analytical procedure itself. The special requirements of various, tryptophan containing matrices were also taken into consideration (biological tissues or fluids, food and feed stuffs, etc). For the sake of completeness in addition to the most common HPLC/UV/F1 techniques, HPLC/MS, GC/MS, CE/UV/F1 and spectrophotometry will be also discussed.
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References
Altria K.D., Harkin P., and Hindson M.G., 1996, Quantitative determination of tryptophan enantiomers by capil-lary electrophoresis, J. Chromatogr. B, 686:103–110.
Aponte R. Linares, Diaz J. Ayala, Perera A. Alfonso, and Diaz V. Gonzales, 1996, Simple thin layer chromatography method with fibre optic remote sensor for fluorometric quantification of tryptophan and related metabolites, J. Liq. Chrom, 19:687–698.
Chan K.C., Muschik G.M., and Issag H.J., 1995, Separation of tryptophan and related indoles by micellar electrokinetic chromatography with KrF laser-induced fluorescence detection, J. Chromatogr., 718:203–210.
Chanut E., Nguyen-Legros J., Versaux-Botterin C., Trouvin J.H., and Launay J.M., 1998, Determination of melatonin in rat pineal, plasma and retina by high-performance liquid chromatography with electrochemical detection, J. Chromatogr. B, 709:11–18.
Chen P., Osborn B.L., and Abramson F.P., 1998, Exemining the origin of melatonin from a “natural” source by izotope ratio mass spectrometry, liquid chromatography introduction, JAOAC International, 81:40–43.
Dobbie M.S. and Surtees A.H., 1997, Concentrations of quinolinic acid in cerebrospinal fluid measured by gas chromatography and electron-impact Ionisation mass spectrometry. Age-related changes in a paediatric, reference population, J. Chromatogr. B, 696:53–58.
Gazy A. Azza, Abdine H. Heba, and Abdel-Hay H.M., 1998, Colorimetric and spectrofluorimetric method for the determination of melatonin in tablets and serum, Spectroscopy Letters, 31:177–197.
Gostkowski M.L., McDoniel J.B., Wei J., Theodore E., and Shear J.B., 1998, Characterizing spectrally diverse biological chromophores using capillary electrophoresis with multiphoton-ecited fluorescence, J. Am. Chem. Soc, 120:18–22.
Gutsche B. and Herderich M., 1998, HPLC-MS/MS identification of tryptophan-derived tetrahydro-β-carboline derivatives in food, Fresenius J. Anal. Chem., 360:836–839.
Gutsche B. and Herderich M., 1997a, HPLC-MS/MS Profiling of tryptophan-derived alkaloids in food: identification of tetrahydro-β-carbolinedicarboxylic acid, J. Agric. Food. Chem., 45:2458–2462.
Gutsche B. and Herderich M., 1997b, HPLC-electrospray ionization-tandem mass spectrometry for the analysis of 1,2,3,4-tetrahydrocarboline derivatives, J. Chromatogr., 767:101–106.
Hansen D.K. and Lunte S.M., 1997, Determination of kynurenic acid by capillary electrophoresis with laser induced fluorescence detection, J. Chromatogr, 781:81–89.
Harumi T., Akutsu H., and Matsushima S., 1996, Simultaneous determination of serotonin, N-acetylserotonin and melatonin in the pineal gland of the juvenile golden hamster by high-performance liquid chromatography with electrochemical detection, J. Chromatogr. B, 675:152–156.
Hervé C., Beyne P., Jamault H., and Delacoux E., 1996, Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection, J. Chromatogr. B, 675:157–161.
Imai J., Yoshida I., Murayama K., Sakai Y., Shimizu H., Sumi T., Iguchi T., Kawai M., and Yamaguchi S., 1996, Determination of the 8-methyl ether of xanturenic acid in human serum by high-performance liquid chromatography with fluorescence detection, J. Chromatogr. B, 679:204–207.
Iwahashi H. and Ishii T., 1997, Detection of the oxidative products of 3-hydroxykynurenine using highperfor-mance liquid chromatography-electrochemical detection-ultraviolet absorption detection-electron spin resonance spectrometry and high-perfomance liquid chromatography-electrochemical detection-ultraviolet adsorption detection-mass spectrometry, J. Chromatogr. 773:23–31.
Kulczykowska E. and Iuvone P.M., 1998, Highly specific and selective assay of plasma melatonin using high-performance liquid chromatography with fluorescence detection presceded by solid phase extraction, J. Chromatogr. Sci., 36:175–178.
Lagana A., Marino A., Fago G., Pardo-Martinez B., and Bizzarri M., 1995, Sensitive assay for melatonin in human serum by liquid chromatography, Anal. Chim. Acta, 316:377–385.
Li J. and Li G., 1998, Identification of 3-hydroxy-kynurenine and xanthurenic acid and quantitation of 3-hydroxykynurenine transaminase activity using HPLC with electrochemical detection, J. Liq. Chrom., 21:1511–1525.
Liu M., Wang G.R., Liu T.Z., and Tsai K.J., 1996, Improved fluorometric quantification of urinary xanthurenic acid, Clin. Chem., 42:397–401.
Malone M.A., Zuo H., Lunte S.M., and Smyth M.R., 1995, Determination of tryptophan and kynurenine in brain microdialysis samples by capillary electrophoresis with electrochemical detection, J. Chromatogr, 700:73–80.
Matysik Frank-Michael, 1996, Improved endcolumn amperometric detection for capillary electrophoresis, J. Chromatogr., 742:229–234.
Mawatari K., Oshida K., Iinuma F., and Watanbe M., 1995, Determination of quinolinic acid in human urine by liquid chromatography with fluorimetric detection, Anal. Chim. Acta, 302:179–183.
Molnár-Perl I., 1996, Advances in Tryptophan Analysis in Peptides and Proteins; In Advances in Experimen tal Medicine and Biology, Vol 398, Recent Advances in Tryptophan Research, (Eds. G. Allegri Filippini, C.V.L. Costa, A. Bertazzo) Plenum Publishing Corporation, New York, pp. 635–649.
Molnár-Perl I. and Bozor I., 1998, Comparison of the stability, UV and fluorescence characteristics of the OPA/3-mercaptopropionic acid-, OPA/N-acetyl-L-cysteine reagents and those of their amino acid derivatives. J. Chromatogr., 798:37–46.
Molnár-Perl I., 1998, Amino acid separation, In Advanced Chromatographic and Electromigration Methods in Bio Sciences, (Eds. Z. Deyl, F. Tagliaro and E. Terasová), Elsevier, Vol 60, Chapter 11, pp. 415–464.
Naritsin D.B., Boni R.L., and Markey S.P., 1995a, Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using elektron capture negative ion mass spectrometry, Anal. Chem., 67:863–870.
Naritsin D.B., Kuniaki Saito, Markey S.P., Chen C.Y., and Heyes M.P., 1995b, Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate, J. Neurechem., 65:2217–2226.
Sanni L.A., Thomas S.R., Tattam B.M., Moore D.E., Geeta Chaudhri, Stocker R., and Hunt N.H., 1998, Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria, Amer. J. Pathol., 152:611–619.
Shinomiya K., Kabasawa Y., and Ito Y., 1998, Enantiomeric separation of commercial D,L-kynurenine with an aqueous two-phase solvent system by cross-axis coil planet centrifuge, J. Liq. Chrom., 21:135–141.
Simat T.J. and Steinhart H., 1998, Oxidation of free tryptophan and tryptophan residues in peptides and proteines, J. Agric. Food Chem., 46:490–498.
Simat T.J., van Wickern B., Eulitz K., and Steinhart H., 1996, Contaminants in biotechnologically manufactured L-tryptophan, J. Chromatogr. B, 685:41–51.
Sitaram B.R., Sitaram M., Traut M., and Chapman C.B., 1995, Nyctohemeral rhythm in the levels of S-Adeno-syl-methionine in the rat pineal gland and its relationship to melatonin biosynthesis, J. Neurochem. 65:1887–1894.
Tsang C.W., Chan C.L., Li P., and Pang S.F., 1996, Analysis of 5-methoxytryptamine at the femtomole level in the rat and quail brain by gas chromatography-electron-capture negative ion chemical ionization masspectrometry, J. Chromatogr., B, 682:185–194.
Ubbink J.B., Schnell A.M., and Rapley C.H., 1988, Quantification of urinary xanthurenic acid excretion by anion exchange solid-phase extraction and high-performance liquid chromatography, J. Chromatogr., 425:182–186.
Vitale A.A., Ferrari C.C., Aldana H., and Affani J.M., 1996, Highly sensitive method for the determination of Melatonin by normal-phase high-performance liquid chromatography with fluorometric detection, J. Chromatogr. B, 681:381–384.
Weber P.L., Malis M., Palmer S.D., Klein T.L., and Lunte S.M., 1997, Capillary zone electrophoresis separation of tryptophan and its metabolites, including quinolinic acid, J. Chromatogr. B, 697:263–268.
Zawilska J. and Iuvone P.M., 1989, Catecholamine receptors regulating serotonin N-acetyltransferase activity and melatonin content of chicken retina and pineal gland, J. Pharmacol. Exp. Therap., 250:86–92.
Xie F., Wong P., Yoshioka K., Cooks G.R., and Kissinger P.T., 1998, Determination of melatonin in commercially available products by LC/EC and LC/MS/MS, J. Liq. Chrom., 21:1273–1282.
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Molnár-Perl, I. (1999). Advances in the Analysis of Tryptophan and its Related Compounds by Chromatography. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_102
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_102
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