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Genetics of Breast and Ovarian Cancer

A Continuum of Risk

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Cancer Genetics for the Clinician

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Abstract

Genetics contributes to the risk of breast and ovarian cancer to a variable degree Rare families show dramatic clustering of breast and ovarian cancer, with cancers occurring at an early age.1 Most such families carry genetic alterations (or mutations) conferring an inherited predisposition to cancer. These families are often referred to as cancer-prone or high risk families; women from these families, if they inherit the cancer predisposition, may face a lifetime probability of cancer as high as 85–90%.1

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Authors and Affiliations

  1. Department of Medicine, University of Washington, 4245 Roosevelt Way NE, Seattle, WA, Box 354765, 98105, USA

    Wylie Burke

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  1. Wylie Burke
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Editors and Affiliations

  1. H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida, USA

    Gail L. Shaw

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© 1999 Springer Science+Business Media New York

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Burke, W. (1999). Genetics of Breast and Ovarian Cancer. In: Shaw, G.L. (eds) Cancer Genetics for the Clinician. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4699-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-4699-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7128-1

  • Online ISBN: 978-1-4615-4699-3

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