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Astrocytes as Active Participants of Glutamatergic Function and Regulators of its Homeostasis

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The Functional Roles of Glial Cells in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 468))

Abstract

Traditionally, glial cells have been considered as supportive elements for neuronal development, function, and survival. However, recent findings are modifying this view, suggesting that glia plays also dynamic roles and actively participates in synaptic function and processing of information in the brain. Astrocytes, the most abundant type of glia in the CNS, are intimately interconnected with nerve cells, and their processes often enwrap synaptic specializations (Pfrieger and Barres, 1996). Their plasma membranes are endowed with a variety of specific transporter proteins which take up synaptically released neurotransmitters such as glutamate and GABA and tightly control their extracellular concentration (e.g. see Chaudry et al., 1995).

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Authors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9-20133, Milan, Italy

    Paola Bezzi, Sabino Vesce, Patrizia Panzarasa & Andrea Volterra

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  1. Paola Bezzi
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  2. Sabino Vesce
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  3. Patrizia Panzarasa
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  4. Andrea Volterra
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Editors and Affiliations

  1. University of Geneva Medical School, Geneva, Switzerland

    Marco Tsacopoulos

  2. Hellenic Pasteur Institute, Athens, Greece

    Rebecca Matsas

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Bezzi, P., Vesce, S., Panzarasa, P., Volterra, A. (1999). Astrocytes as Active Participants of Glutamatergic Function and Regulators of its Homeostasis. In: Matsas, R., Tsacopoulos, M. (eds) The Functional Roles of Glial Cells in Health and Disease. Advances in Experimental Medicine and Biology, vol 468. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4685-6_6

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  • DOI: https://doi.org/10.1007/978-1-4615-4685-6_6

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