Abstract
The adult mammalian central nervous system (CNS), compared to the developing CNS, has very little capacity to support axonal outgrowth. However, in the adult olfactory system, peripheral neurons originating in the olfactory epithelium are continuously replaced throughout life (Graziadei and Monti-Graziadei, 1976, 1979, 1980; Farbman, 1990) and their elongating axons are able to enter and extend within the CNS at the olfactory bulb. When olfactory axons are transected en routeto the bulb their neuronal cell bodies degenerate and are replaced by rapidly differentiating immature neurons from the olfactory mucosa (Graziadei and Monti-Graziadei, 1976, 1980). These neurons are then able to form synapses with their counterpart CNS neurons and re-establish conductivity. The ability of olfactory neurons to form appropriate synaptic fields after transection in the adult olfactory bulb is thought to be in part due to the glial cells that reside in the olfactory bulb, termed olfactory bulb ensheathing cells (OBECs) (Graziadei and Monti-Graziadei, 1979; Raisman, 1985; Doucette, 1990).
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Barnett, S.C., Franceschini, I.A. (1999). Adhesion Molecule Expression and Phenotype of Glial Cells in the Olfactory Tract. In: Matsas, R., Tsacopoulos, M. (eds) The Functional Roles of Glial Cells in Health and Disease. Advances in Experimental Medicine and Biology, vol 468. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4685-6_24
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DOI: https://doi.org/10.1007/978-1-4615-4685-6_24
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