Abstract
While percutaneous revascularization procedures (i.e., angioplasty) can restore luminal flow in atherosclerotic and occluded vessels, initial high success rates ultimately diminish due to gradual reclosure of the vessel over time. This phenomenon, referred to as restenosis, occurs in up to 40% of patients undergoing angioplasty and is a major health hazard. Angioplasty involves high-pressures balloon inflation in the coronary artery that typically causes significant mechanical injury to the intima, often with concomitant rupture of the internal elastic lamina. Smooth muscle cells subsequently migrate from the media to the intima, then proliferate and secrete extracellular matrix producing neointimal hyperplasia and a fibromuscular lesion that may occlude the vessel lumen.
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Paolini, J.F., Edelman, E.R. (2000). Antioxidants and Restenosis: Animal and Clinical Studies. In: Keaney, J.F. (eds) Oxidative Stress and Vascular Disease. Developments in Cardiovascular Medicine, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4649-8_19
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DOI: https://doi.org/10.1007/978-1-4615-4649-8_19
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