Summary
Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines, including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals via JAK/STAT, MAP kinase, and PI3 kinase pathways. Besides various well-established mechanisms by which cardiac growth and myocardial remodeling are regulated, gp130 signaling may be a newly discovered mechanism that regulates these events in association with cytoprotective effects.
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Yamauchi-Takihara, K., Kunisada, K., Fujio, Y., Oh, H., Tone, E., Kishimoto, T. (2000). gp130-Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease. In: Takeda, N., Nagano, M., Dhalla, N.S. (eds) The Hypertrophied Heart. Progress in Experimental Cardiology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4423-4_25
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DOI: https://doi.org/10.1007/978-1-4615-4423-4_25
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