Abstract
A molecular biology view of heart failure identifies various mechanisms of cardiac remodeling and apoptosis. This chapter looks at the role of the gene in the progression of heart failure.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Glennon PE, Sugden PH, Poole-Wilson PA. Cellular mechanisms of cardiac hypertrophy. Br.Heart J. 1995; 73:496–499.
Lee TH, Hamilton MA, Stevenson LW, Moriguchi JD, Fonarow GC, Child JS, et al. Impact of left ventricular cavity size on survival in advanced heart failure. Am.J.Cardiol. 1993; 72:672–676.
Beltrami CA, Finato N, Rocco M, Feruglio GA, Puricelli C, Cigola E, Quaini F, Sonnenblick EH, Olivetti G, Anversa P. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation. 1994; 89:151–163.
Roberts WC, Siegel RJ and McManus BM. Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients. Am.J.Cardiol. 1987; 60:1340–1355.
Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, et al. Apoptosis in the failing human heart. N.Engl.J.Med. 1997; 336:1131–1141.
Blum A, Miller H. Role of cytokines in heart failure. Am.Heart J. 1998; 135:181–186.
McKenna CJ, Sugrue DD, Kwon HM, Sangiorgi G, Carlson PJ, Mahon N, McCann HA, Edwards WD, Holmes DRJ, Schwartz RS. Histopathologic changes in asymptomatic relatives of patients with idiopathic dilated cardiomyopathy. Am.J. Cardiol. 1999; 83:281–283, A6.
Sharov VG, Sabbah HN, Shimoyama H, Goussev AV, Lesch M, Goldstein S. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am.J.Pathol. 1996; 148:141–149.
Boluyt MO, Bing OH, Lakatta EG. The ageing spontaneously hypertensive rat as a model of the transition from stable compensated hypertrophy to heart failure. Eur.Heart J. 1995; 16 (Suppl N):19–30.
Francis GS. TNF-alpha and heart failure: the difference between proof of principle and hypothesis testing. Circulation. 1999; 99:3213–3214.
Bristow MR. Tumor necrosis factor-alpha and cardiomyopathy. Circulation. 1998; 97:1340–1341.
Satoh M, Nakamura M, Tamura G, Makita S, Segawa I, Tashiro A, et al. Inducible nitric oxide synthase and tumor necrosis factor-alpha in myocardium in human dilated cardiomyopathy. J.Am.Coll.Cardiol. 1997; 29:716–724.
Deswal A, Bozkurt B, Seta Y, Parilti-Eiswirth S, Hayes FA, Blosch C, Mann DL. Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure. Circulation. 1999; 99:3224–3226.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jaski, B.E. (2000). Gene. In: Basics of Heart Failure. Developments in Cardiovascular Medicine, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4379-4_8
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4379-4_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6969-1
Online ISBN: 978-1-4615-4379-4
eBook Packages: Springer Book Archive