Drosophila Projectin: A Look at Protein Structure and Sarcomeric Assembly

  • Agnes Ayme-Southgate
  • Richard Southgate
  • Michelle Kulp McEliece
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 481)


The large projectin protein is found in all Drosophila muscles; however, it shows a dual sarcomeric localization depending on the muscle type. In larval and adult synchronous muscles, projectin is found localized over the A-band. Initial in vitro binding assays indicate interactions of several projectin regions with themselves and myosin heavy chain. These interactions might be critical for the assembly of projectin over the myosin filament during embryonic myofibrillogenesis and larval growth. On the other hand, projectin localizes over the I-Z-I region in indirect flight muscles. Correspondingly, projectin is found in association with forming Z-bands during pupation and colocalizes with α-actinin and kettin.


Myosin Heavy Chain Flight Muscle Thick Filament Myosin Filament Stagger Arrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Agnes Ayme-Southgate
    • 1
  • Richard Southgate
    • 1
  • Michelle Kulp McEliece
    • 2
  1. 1.Department of BiologyCollege of CharlestonCharlestonUSA
  2. 2.Department of Biological SciencesLehigh UniversityBethelehemUSA

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