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Chronic Pain: Somatic or Limbic Mechanisms

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Pain and Neuroimmune Interactions

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Abstract

In the field of nociception and pain, the highly distributed nature of neural pathways, relay centers and their ultimate destination in the brain fits well with the thesis that pain perception is only one part of a multisystem reaction to injury or inflmmation which involves simultaneous activation of the immune, endocrine, cardiovascular and rrespiratory systems. In particular, the immune and nerveous systems interact, via neural and humoral loops, at peripharal and central levels in the nervous system. Evidence is presented to support a very important role for the limbic system in these interactions and to regard chronic pain as a corollary of the inbalance in the cross-talk between the immune and the nervous systems.

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Author information

Authors and Affiliations

  1. Departments of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Suhayl J. Jabbur & Nayef E. Saadé

  2. Departments of Human Morphology Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Nayef E. Saadé

  3. Departments of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Samir F. Atweh

Authors
  1. Suhayl J. Jabbur
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  2. Nayef E. Saadé
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  3. Samir F. Atweh
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Editors and Affiliations

  1. American University of Beirut, Beirut, Lebanon

    Nayef E. Saadé  & Suhayl J. Jabbur  & 

  2. SUNY Health Science Center, Syracuse, New York, USA

    A. Vania Apkarian

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Jabbur, S.J., Saadé, N.E., Atweh, S.F. (2000). Chronic Pain: Somatic or Limbic Mechanisms. In: Saadé, N.E., Apkarian, A.V., Jabbur, S.J. (eds) Pain and Neuroimmune Interactions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4225-4_17

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  • DOI: https://doi.org/10.1007/978-1-4615-4225-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6897-7

  • Online ISBN: 978-1-4615-4225-4

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