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Handbook of Cross-Cultural Neuropsychology pp 361–369Cite as

Neurobehavioral Disorders and Pharmacologic Intervention

The Significance of Ethnobiological Variation in Drug Responsivity

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Part of the book series: Critical Issues in Neuropsychology ((CINP))

Abstract

The Epidemiological Catchment Area Study has determined that the lifetime prevalence of any mental disorder in the United States is 33% (Marzuk, 1993). More than half of the patients with mental disorders are treated by primary care physicians and fewer than 20% receive treatment in specialized mental health settings (Simon, 1992). This is particularly true for anxiety and depression, which are among the most common of the mental disorders (Simon, 1992). Family physicians treat approximately 90% of anxiety disorders (Narrow, Regier, Rae, Manderscheid, & Locke, 1993). Surveys of outpatients in primary care settings demonstrate 6%–8% are suffering from a major depressive disorder (Walley, Beebe, & Clark, 1994) that is frequently associated with high levels of medical utilization (Depression Guideline Panel of the Agency for Healthcare Policy and Research, 1994). This pattern of health care delivery is also true of African American patients (Lin & Poland, 1994). While these disorders are clearly treatable, they can be difficult to manage and may require attention to many patient variables, including interethnic pharmacogenetic, pharmacokinetic, and pharmacodynamic differences. When primary care physicians refer their patients to mental health specialists, as many as half do not complete the referral (Schulberg, Coulchan, Black, et al., 1993). Also, pharmacotherapy with elderly populations is a significant concern as this patient population typically presents with multiple compounds on board and is at high risk for renal and hepatic pathologies that have profound implications for safety.

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Author information

Authors and Affiliations

  1. Charles R. Drew University of Medicine and Science, Los Angeles, California, 90059, USA

    Tony L. Strickland & Gregory Gray

  2. UCLA School of Medicine, Los Angeles, California, 90095, USA

    Tony L. Strickland & Gregory Gray

Authors
  1. Tony L. Strickland
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  2. Gregory Gray
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Editor information

Editors and Affiliations

  1. University of Northern Colorado, Colorado Springs, Colorado, USA

    Elaine Fletcher-Janzen

  2. Drew University of Medicine and Science, Los Angeles, California, USA

    Tony L. Strickland

  3. UCLA School of Medicine, Los Angeles, California, USA

    Tony L. Strickland

  4. Texas A&M University, College Station, Texas, USA

    Cecil R. Reynolds

  5. Bastrop Mental Health Associates, Bastrop, Texas, USA

    Cecil R. Reynolds

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© 2000 Springer Science+Business Media New York

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Strickland, T.L., Gray, G. (2000). Neurobehavioral Disorders and Pharmacologic Intervention. In: Fletcher-Janzen, E., Strickland, T.L., Reynolds, C.R. (eds) Handbook of Cross-Cultural Neuropsychology. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4219-3_21

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  • DOI: https://doi.org/10.1007/978-1-4615-4219-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6894-6

  • Online ISBN: 978-1-4615-4219-3

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