Abstract
Many plants have long been used as traditional herbal medicines. Because chronic disorders of an endogenous nature and pressing medical problems such as non-specific, constitutional or psychosomatic diseases have increased during the second half of the 20th century, traditional herbal medicines have begun to attract worldwide attention (Yamada 1994a). Herbal extracts used in Sino-Japanese traditional herbal medicines contain both low- and high-molecular-weight substances. The former include alkaloids, terpenoids, saponins and flavonoids, whereas the latter include proteins, tannins and polysaccharides in the hot water extract. Although biologically active substances with low molecular weight in medicinal herbs have been well studied and characterized, they can not account for all of the clinical effects achieved. Among the high-molecular-weight components of medicinal herbs, polysaccharides have been shown to possess a variety of pharmacological activities. Most especially, pectic polysaccharides containing arabinogalactan have been shown to have immunostimulating, antiulcer, anti-metastasis, hypoglycemic or other activities. (Yamada 1994b 1996, Yamada and Kiyohara 1999). These observations suggest that pectic polysaccharides are involved in the efficacy of traditional herbal medicines.
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References
Hirano, M., Kiyohara, H., Matsumoto, T., and Yamada, H., 1994, Structural studies of endo-polygalacturonase-resistant fragments in anti-ulcer pectin from the roots of Bupleurum falcatum L., Carbohyd. Res. 251: 145–162.
Hong, T., Matsumoto, T., Kiyohara, H., and Yamada, H., 1998, Enhanced production of hematopoietic growth factors through T cell activation in Peyer’s patches by oral administration of Kampo (Japanese herbal) medicines, “Juzen-taiho-to”, Phytomedicine 5: 353–360.
Kiyohara, H., Cyong, J-C, and Yamada, H., 1988, Structure and anti-complementary activity of pectic polysaccharides isolated form the roots of Angelica acutiloba Kitagawa, Carbohyd. Res. 182: 259–275.
Kiyohara, H., Zhang, Y-W., and Yamada, H., 1997, Effect of exo-β-D(1→3)-galactanase digestion on complement activating activity of neutral arabinogalactan unit in a pectic arabinogalactan from roots of Angelica acutiloba Kitagawa, Carbohyd. Polym. 32: 249–253.
Sakurai, M., Matsumoto, T., Kiyohara, H., and Yamada, H.,1996, Detection and tissue distribution of anti-ulcer polysaccharides from Bupleurum falcatum L. by polyclonal antibody, Planta Med. 62: 341–346.
Sakurai, M., Kiyohara, H., Matsumoto, T., Tsumuraya, Y., Hashimoto, Y., and Yamada, H., 1998, Characterization of antigenic epitopes in anti-ulcer pectic polysaccharides from Bupleurum falcatum L. using several carbohydrases, Carbohyd. Res. 311: 219–229.
Sakurai, M. H., Matsumoto, T., Kiyohara, H., and Yamada, H., 1999, B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement, Immunology 97: 540–547.
Yamada, H., 1994a, Modern scientific approaches to kampo medicine, Asia Pacific J. Pharmacol. 9: 209–217.
Yamada, H., 1994b, Pectic polysaccharides from Chinese herbs: Structure and biological activity, Carbohyd. Polym., 25: 269–276.
Yamada, H., 1996, Contribution of pectins on health care, In Pectin and Pectinase Progress in Biotechnology, Vol. 4 (J. Visser and A. G. J. Voragen, eds.), Elsevier, Amsterdam, pp. 173–190.
Yamada. H., and Kiyohara, H., 1999, Complement-activating polysaccharides from medicinal herbs, In Immunomodulatory Agents from Plants (H. Wagner, ed.), Birkhauser Verlag, Basel, pp. 161–202.
Yamada, H., Kiyohara, H., Cyong, J-C, and Otsuka, Y., 1987, Structural characterization of an anti-complementary arabinogalactan form the roots of Angelica acutiloba Kitagawa, Carbohyd. Res. 159:275–291.
Yamada, H., Sun, X-B., Matsumoto, T., Ra, K-S., Hirano, M., and Kiyohara, H., 1991a, Purification of anti-ulcer polysaccharides from the roots of Bupleurum falcatum L., Planta Med. 57: 555–559.
Yamada, H., Hirano, M., and Kiyohara, H., 1991b, Partial structure of an anti-ulcer pectic polysaccharide from the roots of Bupleurum falcatum L., Carbohyd. Res. 219: 173–192.
Yu, K-W., Kiyohara, H., Matsumoto, T., Yang, H-C, and Yamada, H., 1998, Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea, Planta Med. 64: 714–719.
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© 2000 Springer Science+Business Media New York
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Yamada, H. (2000). Bioactive Arabinogalactan-Proteins and Related Pectic Polysaccharides in Sino-Japanese Herbal Medicines. In: Nothnagel, E.A., Bacic, A., Clarke, A.E. (eds) Cell and Developmental Biology of Arabinogalactan-Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4207-0_19
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DOI: https://doi.org/10.1007/978-1-4615-4207-0_19
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