Abstract
In the past several years, significant advances in the area of genome modification have taken place. In some cases, the objective has been to block RNA synthesis and change developmental progression (1), while in other cases more permanent alteration at the chromosomal level has been attempted (2). These types of approaches seek not to replace traditional protocols of gene knock-out, gene knock-in or gene replacement, but rather augment them, adding to the arsenal of techniques available to workers who wish to study functional aspects of gene expression. In fact, since the strategies for creating mouse knock-outs first became available, relatively little improvement in the rate of success has occurred.
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Kmiec, E.B., Ye, S., Peng, L. (2000). Targeted Gene Repair in Mammalian Cells Using Chimeric Oligonucleotides. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4199-8_3
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DOI: https://doi.org/10.1007/978-1-4615-4199-8_3
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