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Colonic Cell Proliferation, Differentiation, and Apoptosis

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Colon Cancer Prevention

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 470))

Abstract

Homeostasis in the colonic epithelium is established by maintaining a balance among proliferating, differentiating, and apoptotic cells. This balance is regulated by a complex interaction of intrinsic genetic signals with external stimuli including growth and dietary factors. Moreover, the interaction of signals maintains not only the quantitative balance between dividing and terminally differentiated cells, but a spatial and temporal coordination of cell proliferation, differentiation, and apoptosis within the crypt architecture as well.

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Authors and Affiliations

  1. Albert Einstein Cancer Center, Montefiore Medical Center, 111 East 210th St., Bronx, 10467, New York, USA

    Leonard Augenlicht, Anna Velcich, John Mariadason, Michael Bordonaro & Barbara Heerdt

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  1. Leonard Augenlicht
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  2. Anna Velcich
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  3. John Mariadason
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  4. Michael Bordonaro
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  5. Barbara Heerdt
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    © 1999 Springer Science+Business Media New York

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    Augenlicht, L., Velcich, A., Mariadason, J., Bordonaro, M., Heerdt, B. (1999). Colonic Cell Proliferation, Differentiation, and Apoptosis. In: Colon Cancer Prevention. Advances in Experimental Medicine and Biology, vol 470. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4149-3_2

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    • DOI: https://doi.org/10.1007/978-1-4615-4149-3_2

    • Publisher Name: Springer, Boston, MA

    • Print ISBN: 978-1-4613-6861-8

    • Online ISBN: 978-1-4615-4149-3

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