Abstract
Colon cancer is one of the most familial malignancies in man. There are rare syndromes of colon cancer, but also frequent familial clusters in excess of that expected by chance. The genes that are mutated in the rare syndromes are now known and the cellular processes related to these genes are being elucidated. Common familial clustering is also thought to arise from inherited susceptibility, based on segregation studies, but the underlying genes have not yet been identified. This section will summarize present knowledge of both the rare and more common forms of familial colon cancer.
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Burt, R.W. (1999). Familial Association. In: Colon Cancer Prevention. Advances in Experimental Medicine and Biology, vol 470. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4149-3_11
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DOI: https://doi.org/10.1007/978-1-4615-4149-3_11
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