Abstract
Most colorectal cancers are sporadic but the lifetime risk for this cancer increases with the number of affected individuals in the pedigree. The presence of three affected relatives from two generations is compatible with autosomal dominant inheritance and fulfils the international diagnostic (”Amsterdam”) criteria for hereditary non-polyposis colorectal cancer, HNPCC.1
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Peltomäki, P. (1999). The Genetics of Hereditary Non-Polyposis Colorectal Cancer and Non-Polypotic Colon Cancer. In: Colon Cancer Prevention. Advances in Experimental Medicine and Biology, vol 470. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4149-3_10
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DOI: https://doi.org/10.1007/978-1-4615-4149-3_10
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