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Of Mice, Calves, and Men

Comparison of the Mouse Typhoid Model with Other Salmonella Infections

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Mechanisms in the Pathogenesis of Enteric Diseases 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 473))

Summary

Numerous Salmonella typhimurium virulence factors have been identified and characterized using experimental infection of mice. While the murine typhoid model has been used successfully for Salmonella typhi vaccine development and to infer virulence mechanisms important during typhoid fever, information derived from infection of mice has been of limited value in elucidating the mechanism by which S. typhimurium causes enteritis in humans. Progress in our understanding of virulence mechanisms contributing to diarrheal disease comes from recent studies of bovine enteritis, a S. typhimurium infection, which manifests as acute gastroenteritis. This review compares virulence genes and mechanisms required during murine typhoid, typhoid fever, and bovine enteritis. Comparison of illnesses caused in different animal hosts identifies virulence mechanisms involved in species specific disease manifestations. The determination of the relative importance of virulence factors for disease manifestations in different host species provides an important link between the in vitro characterization of genes and their role during host pathogen interaction.

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Authors and Affiliations

  1. Department of Veterinary Pathobiology College of Veterinary Medicine, Texas A&M University, College Station, Texas, 77843-4467, USA

    Renée M. Tsolis, Thomas A. Ficht & L. Garry Adams

  2. Department of Medical Microbiology and Immunology College of Medicine, Texas A&M University Health Science Center, 407 Reynolds Medical Building, College Station, Texas, 77843-1114, USA

    Robert A. Kingsley, Stacy M. Townsend & Andreas J. Bäumler

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  1. Renée M. Tsolis
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  2. Robert A. Kingsley
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  3. Stacy M. Townsend
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  4. Thomas A. Ficht
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  5. L. Garry Adams
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  6. Andreas J. Bäumler
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Editors and Affiliations

  1. Iowa State University, Ames, Iowa, USA

    Prem S. Paul

  2. South Dakota State University, Brookings, South Dakota, USA

    David H. Francis

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© 1999 Springer Science+Business Media New York

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Tsolis, R.M., Kingsley, R.A., Townsend, S.M., Ficht, T.A., Adams, L.G., Bäumler, A.J. (1999). Of Mice, Calves, and Men. In: Paul, P.S., Francis, D.H. (eds) Mechanisms in the Pathogenesis of Enteric Diseases 2. Advances in Experimental Medicine and Biology, vol 473. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4143-1_28

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  • DOI: https://doi.org/10.1007/978-1-4615-4143-1_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6858-8

  • Online ISBN: 978-1-4615-4143-1

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