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Prospects and Progress in Ellagitannin Synthesis

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Plant Polyphenols 2

Part of the book series: Basic Life Sciences ((BLSC,volume 66))

Abstract

The ellagitannin family of secondary plant metabolites presents a rich array of challenges for contemporary organic synthesis. The myriad intra- and inter-molecular coupling modes available to galloyl rings appended to a glucose core, along with a range of post-coupling modifications, define a vast matrix of bond-forming possibilities, many of which are represented within the 500+ structurally characterized members.1–4 A heightened interest in this class of natural products is fueled by recent observations that several ellagitannins display remarkable levels of activity in various anticancer and antiviral assays and hence may serve as promising leads for development of novel therapeutics.3,5–7 Progress toward that goal will benefit from access to significant quantities of natural material as well as designed analogs for delineation of structure/activity profiles and elucidation of biological mechanism-of-action. These latter goals, and possibly the former goal as well, can only be met through a program of total chemical synthesis.

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Author information

Authors and Affiliations

  1. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA

    Ken S. Feldman, Kiran Sahasrabudhe, Kendra L. Hunter & Michael D. Lawlor

  2. Laboratoire de Chimie des Substances Végétales, Institut du Pin—Université Bordeaux I, 351 cours de la Libération, 33405, Talance, France

    Stéphane Quideau

Authors
  1. Ken S. Feldman
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  2. Kiran Sahasrabudhe
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  3. Stéphane Quideau
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  4. Kendra L. Hunter
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  5. Michael D. Lawlor
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Editor information

Editors and Affiliations

  1. University of Ulm, Ulm, Germany

    Georg G. Gross

  2. United States Department of Agriculture, Forest Service, Pineville, Louisiana, USA

    Richard W. Hemingway

  3. University of Okayama, Okayama, Japan

    Takashi Yoshida

  4. Kenner, Louisiana, USA

    Susan J. Branham

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© 1999 Kluwer Academic / Plenum Publishers, New York

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Feldman, K.S., Sahasrabudhe, K., Quideau, S., Hunter, K.L., Lawlor, M.D. (1999). Prospects and Progress in Ellagitannin Synthesis. In: Gross, G.G., Hemingway, R.W., Yoshida, T., Branham, S.J. (eds) Plant Polyphenols 2. Basic Life Sciences, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4139-4_6

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  • DOI: https://doi.org/10.1007/978-1-4615-4139-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46218-4

  • Online ISBN: 978-1-4615-4139-4

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