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Antiatherogenic Effects of Tea Polyphenols (Flavan-3-ols) in Humans and ApoE-Deficient Mice

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Plant Polyphenols 2

Part of the book series: Basic Life Sciences ((BLSC,volume 66))

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Abstract

In the subendothelial space, low-density lipoproteins (LDL) are converted to oxidized forms through contact with macrophages, endothelial and smooth muscle cells.1 Oxidatively modified LDL have chemotactic properties and recruit blood monocytes developing into tissue macrophages. In addition, modified LDL are taken up into macrophages through scavenger receptors to convert to lipid-laden foam cells. Thus, the prevention of LDL oxidation is assumed to be one of the initial and critical measures for antiatherosclerosis.

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Authors and Affiliations

  1. Graduate School of Health Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan

    Takako Tomita, Eiji Kawai & Masahiko Ikeda

  2. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan

    Yukiko Miura, Tsuyoshi Chiba, Shinji Miura & Isao Tomita

  3. National Institute of Nutrition and Health, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan

    Keizo Umegaki

  4. Central Pharmaceutical Research Institute, Japan Tobacco Inc, 23 Nakogi, Hatano, Kanagawa, 257-0024, Japan

    Haruko Koizumi

Authors
  1. Takako Tomita
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  2. Yukiko Miura
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  3. Tsuyoshi Chiba
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  4. Eiji Kawai
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  5. Keizo Umegaki
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  6. Shinji Miura
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  7. Haruko Koizumi
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  8. Masahiko Ikeda
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  9. Isao Tomita
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Editor information

Editors and Affiliations

  1. University of Ulm, Ulm, Germany

    Georg G. Gross

  2. United States Department of Agriculture, Forest Service, Pineville, Louisiana, USA

    Richard W. Hemingway

  3. University of Okayama, Okayama, Japan

    Takashi Yoshida

  4. Kenner, Louisiana, USA

    Susan J. Branham

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© 1999 Kluwer Academic / Plenum Publishers, New York

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Tomita, T. et al. (1999). Antiatherogenic Effects of Tea Polyphenols (Flavan-3-ols) in Humans and ApoE-Deficient Mice. In: Gross, G.G., Hemingway, R.W., Yoshida, T., Branham, S.J. (eds) Plant Polyphenols 2. Basic Life Sciences, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4139-4_25

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  • DOI: https://doi.org/10.1007/978-1-4615-4139-4_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46218-4

  • Online ISBN: 978-1-4615-4139-4

  • eBook Packages: Springer Book Archive

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