Modeling Neural Systems: Interactions Between Mathematical Analysis, Simulation, and Experimentation in the Lamprey

Abstract

Detailed information about the nervous system has been increasing at a phenomenal rate in the last two decades, but data accumulation does not automatically increase knowledge. At all levels of study in the nervous system, from channels to perception, it is often difficult to understand intuitively how a multicomponent system produces its output. Many neuroscientists have turned to modeling, as a help in understanding complex interactions. As illustrated in the current volume, efforts at modeling are being made at many different levels, from ion channels to large neuronal assemblies. In this chapter, we will be presenting an analytical model of intersegmental coordination in the lamprey, and discussing how this approach relates to network models of the lamprey CPG. We will end with some personal views on the pitfalls and benefits of modeling.