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Accurate Measurement of Glomerular Filtration Rate

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International Yearbook of Nephrology 1991

Part of the book series: International Yearbook of Nephrology 1991 ((IYNE,volume 3))

Abstract

Measurement of the glomerular filtration rate (GFR) in patients with chronic renal disease has recently assumed increasing importance. Responsibility for this evolutionary change can be directly traced to our understanding of the limitations of plasma creatinine and creatinine clearance as markers of GFR (1,2) and the need for accurate and precise quantitation of GFR as potential therapies for progressive renal disease are being evaluated (3). Traditional methods for measurement of GFR are accurate but cumbersome and inconvenient for patients. Newer methods are sometimes less accurate but offer advantages of reproducibility and are more readily implemented. In this review, we discuss the attributes and limitations of different methods and markers for the assessment of GFR with an emphasis on clearance using radioisotopic markers.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, 02111, USA

    Jeffrey G. Mulhern & Ronald D. Perrone

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  1. Jeffrey G. Mulhern
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  2. Ronald D. Perrone
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Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. Division of Nephrology, UCLA School of Medicine, University of California, Los Angeles, California, USA

    Leon G. Fine

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Mulhern, J.G., Perrone, R.D. (1990). Accurate Measurement of Glomerular Filtration Rate. In: Andreucci, V.E., Fine, L.G. (eds) International Yearbook of Nephrology 1991. International Yearbook of Nephrology 1991, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3946-9_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3946-9_14

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-3946-9

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