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Endothelin and Endothelium-Derived Relaxing Factor in the Control of Glomerular Filtration and Renal Blood Flow

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International Yearbook of Nephrology 1991

Part of the book series: International Yearbook of Nephrology 1991 ((IYNE,volume 3))

Abstract

The functional importance of the vascular endothelium in the regulation of local vascular smooth muscle and organ blood flow is now well-established. Since the discovery of endothelial-derived relaxing factor (EDRF) (1), a variety of biochemical and mechanical stimuli have been shown to induce the release of endothlial-derived relaxing or contracting factors. It seems likely that EDRF is nitric oxide (2) and it now appears that endothelial-derived contracting factor (EDCF) is primarily the peptides in the endothelin family (3–5).

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Vanderbilt University Kidney and Urologie Disease Center; Vanderbilt University, Nashville, Tennessee, 37232, USA

    Kihito Takahashi, Tetsuo Katoh & Kamal F. Badr

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  1. Kihito Takahashi
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  2. Tetsuo Katoh
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  3. Kamal F. Badr
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Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. Division of Nephrology, UCLA School of Medicine, University of California, Los Angeles, California, USA

    Leon G. Fine

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Takahashi, K., Katoh, T., Badr, K.F. (1990). Endothelin and Endothelium-Derived Relaxing Factor in the Control of Glomerular Filtration and Renal Blood Flow. In: Andreucci, V.E., Fine, L.G. (eds) International Yearbook of Nephrology 1991. International Yearbook of Nephrology 1991, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3946-9_1

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