Skip to main content
SpringerLink
Log in

Epidermal Dendritic Cells in Immunodeficient Mice

  • Chapter
Book cover Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS

Part of the book series: Developments in Medical Virology ((DIMV,volume 7))

  • 51 Accesses

Abstract

The expression of Ia+ Langerhans cells (LC) and Thy-1+ dendritic epidermal cells (Thy-1+DEC) was investigated in the skin of C57BL/6J mice homozygous for the viable motheaten, beige, rhino or nude mutations. These mutations cause various types of immunodeficiencies associated with abnormalities in skin structure. At one month of age viable motheaten (me v) mice possess normal numbers of LC compared with control heterozygotes. However by five weeks, LC density decreases in me v/me v homozygotes reaching 404±119 cells/mm2 compared with 1198 ± 215 in control heterozygotes (p <; 0.002). This decrease in LC numbers correlates with a decrease in the number of interdigitating cells (IDC) isolated from the draining lymph nodes of motheaten mice. However, the ability of remaining viable motheaten mice-derived LC to transport antigens from the skin to the lymph nodes is retained. Nude mice possess significantly decreased numbers of Thy-1+DEC compared with heterozygote controls from the age of four months. Rhino mice possess significantly increased numbers of Thy-1+DEC at all ages tested. Thus these studies define autosomal recessive mutations in mice that are accompanied by striking changes in the numbers and function of epidermal dendritic cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tschachler E., Shuler G., Hutterer J., Leibl H., Wolff K. and Stingl G. J. Invest. Dermatol., 81:282–285, 1983.

    Article  PubMed  CAS  Google Scholar 

  2. Bergstresser P.R., Tigelaar R.E., Dees J.H. and Streilein J.W. J. Invest. Dermatol., 81:286–288, 1983.

    Article  PubMed  CAS  Google Scholar 

  3. Choi LC and Sauder DN. J Leuk Biol 39:343–358, 1986.

    CAS  Google Scholar 

  4. Breathnach S.M. and Katz S.I. 83:74–77, 1984.

    Google Scholar 

  5. Katz S.I., Tamaki K. and Sachs D.H. Nature, 282:324–326, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Mackenzie I.C. and Squier C.A. Br. J. Dermatol., 92:523–533, 1975.

    Article  PubMed  CAS  Google Scholar 

  7. Tamaki K., Stingl G., Gullino M., Sachs D.H. and Katz S.I. J. Immunol., 123:784–787, 1979.

    PubMed  CAS  Google Scholar 

  8. Kraal G., Breel M., Janse M. and Bruin G. J. Exp. Med., 163:981–997, 1986.

    Article  PubMed  CAS  Google Scholar 

  9. Balfour B.M., Drexhage H.A., Kamperdijk E.W.A. and Hoefsmit E.C.M. in Microenvironments in haematopoietic and lymphoid differentiation, Ciba Foundation Symposium, 84:281–301, 1981.

    CAS  Google Scholar 

  10. Silberberg I., Baer R.L. and Rosenthal S.A. J. Invest. Dermatol., 66:210–217, 1976.

    Article  PubMed  CAS  Google Scholar 

  11. Romani N., Stingl G., Tschachler E., Witmer M.D., Steinman R.M., Shevach E.M. and Schuler G. J. Exp. Med., 161:1368–1383, 1985.

    Article  PubMed  CAS  Google Scholar 

  12. Tschachler E., Steiner G., Yamada H., Elbe A., Wolff K. and Stingl G. J. Invest. Dermatol., 92:763–768, 1989.

    Article  PubMed  CAS  Google Scholar 

  13. Nixon-Fulton J.L., Kuziel W.A., Santerse B., Bergstresser P.R., Tucker P.W. and Tigelaar R.E. J. Immunol., 141:1897–1903, 1988.

    PubMed  CAS  Google Scholar 

  14. Asarnow D.M., Kuziel W.A., Bonyhadi M., Tigelaar R.E., Yucker P.W. and Allison J.P. Cell, 55:837–847, 1988.

    Article  PubMed  CAS  Google Scholar 

  15. Steiner G., Koning F., Elbe A., Tschachler E., Yokoyama W.M., Shevach E.M., Stingl G. and Coligan J.E., 18:1323–1328, 1988.

    Google Scholar 

  16. Shultz L.D. and Sidman C.L. Ann. Rev. Immunol., 5:367, 1987.

    Article  CAS  Google Scholar 

  17. Shultz L.D. Curr. Probl. Derm., 17:236–250, 1987.

    PubMed  CAS  Google Scholar 

  18. Green M.C. and Shultz L.D. J. Hered., 66:250–258, 1975.

    PubMed  CAS  Google Scholar 

  19. Lutzner M.A. and Hansen C.T. J. Immunol., 116:1496–1497, 1976.

    PubMed  CAS  Google Scholar 

  20. Shultz L.D., Coman D.R., Bailey C.L. Beamer W.G. and Sidman C.L. Am. J. Pathol., 116:179–192, 1984

    PubMed  CAS  Google Scholar 

  21. Ward J.M. Vet. Pathol., 15:170–178, 1978.

    Article  PubMed  CAS  Google Scholar 

  22. Shultz L.D. and Green M.C. J. Immunol., 116:936–943, 1976.

    PubMed  CAS  Google Scholar 

  23. Sidman C.L., Shultz L.D. and Unanue E.R. J. Immunol., 121:2399–2404, 1978.

    PubMed  CAS  Google Scholar 

  24. Clark E.A. and Shultz L.D. Immunogenetics, 12:601–613, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. McCoy K.L., Chi E., Engel E. and Clagget J. Am. J. Pathol., 112:18–26, 1983.

    PubMed  CAS  Google Scholar 

  26. Sidman C.L., Marshall J.D., Masiello N., Roths J.B., Shultz L.D., Proc. Natl. Acad. Sci., 81:7199–7202, 1984.

    Article  PubMed  CAS  Google Scholar 

  27. Shultz L.D., Coman D.R., Sidman C.L. and Lyons B. Am. J. Pathol., 127:38–90, 1987.

    PubMed  CAS  Google Scholar 

  28. Sidman C.L., Shultz L.D., Hardy R.R., Hayakawa K. and Herzenberg L. Science, 232:1423–1425, 1986.

    Article  PubMed  CAS  Google Scholar 

  29. Greiner D.L., Goldschneider I., Komschlies K.L., Medlock E.S., Bollum F.J. and Shultz L.D. J. Exp. Med., 164:1129–1144, 1986.

    Article  PubMed  CAS  Google Scholar 

  30. Komschlies K.L., Greiner D.L., Shultz L.D. and Goldschneider I. J. Exp. Med., 166:1162–1167, 1987.

    Article  PubMed  CAS  Google Scholar 

  31. Van Zant G. and Shultz L. Exp. Hematol., 17:81–87, 1989.

    PubMed  Google Scholar 

  32. Roder J. and Duwe A. Nature, 278:451–453, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Biron C.A., Pedersen K.F. and Welsh R.M. J. Immunol., 138:2050–2056, 1987.

    PubMed  CAS  Google Scholar 

  34. Carlson G.A., Marshall S.T., Truesdale A.T. Cell. Immunol., 87:348–356, 1984.

    Article  PubMed  CAS  Google Scholar 

  35. Mahoney K.H., Morse S.S. and Morahan P.S. Cancer Res., 40:3934–3939, 1980.

    PubMed  CAS  Google Scholar 

  36. Mann S.J. Anat. Rec, 170:845–500, 1971.

    Article  Google Scholar 

  37. Kawaji H. Exp. Animals, 22:299s, 1973.

    Google Scholar 

  38. Takaoki M. and Kawaji H. Immunology, 40:27–31, 1980.

    PubMed  CAS  Google Scholar 

  39. Kawaji H., Tsukuda R. and Nakagushi T. Acta Pathol. Jpn, 30:515–519, 1980.

    PubMed  CAS  Google Scholar 

  40. Baker K.W. and Habowsky J.E.J.J. Invest. Dermatol., 80:104–107, 1983.

    Article  CAS  Google Scholar 

  41. Nordlund J.J. and Ackles A. Tissue Antigens, 17:217–225, 1981.

    Article  PubMed  CAS  Google Scholar 

  42. Macatonia S.E., Edwards A.J. and Knight S.E. Immunology, 59:509–514, 1986.

    PubMed  CAS  Google Scholar 

  43. Knight S.C., Mertin J., Stackpole A and Clark J. Proc. Natl. Acad. Sci., 80:6032–6035, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Sprecher E., Becker Y., Kraal G., Hall E. and Shultz L.D. Arch. Dermatol. Res. (in press).

    Google Scholar 

  45. Macatonia S.E., Knight S.E., Edwards A.J. Griffiths S. and Fryer P. J. Exp. Med., 166:1654–1667, 1987.

    Article  PubMed  CAS  Google Scholar 

  46. Thomas W.R., Edwards A.J., Watkins M.C. and Asherson G.L. Immunology, 39:21–27, 1980.

    PubMed  CAS  Google Scholar 

  47. Krueger, G.G. and Mansoor, E., J. Invest. Dermatol. 82:613–617, 1984.

    Article  PubMed  CAS  Google Scholar 

  48. Cole S. and Townsend M.S. Rad. Res., 103:251–259, 1985.

    Article  CAS  Google Scholar 

  49. Aberer W., Romani N., Elbe A. and Stingl G. J. Immunol., 136:1210–1216, 1986.

    PubMed  CAS  Google Scholar 

  50. Ghaznawie M., Papadimitriou J.M. and Heenan P.J. Br. J. Dermatol., 120:341–349, 1989.

    Article  PubMed  CAS  Google Scholar 

  51. Rheins L.A. and Nordlund J.J. J. Immunol., 136:867–876, 1986.

    PubMed  CAS  Google Scholar 

  52. Shiohara T., Koyobashi M., Narimatsu H. and Nagashima M. Arch. Dermatol. Res., 279:198–203, 1987.

    Article  PubMed  CAS  Google Scholar 

  53. Larsen C.G., Ternowitz T., Larsen F.G. and Thestrup-Pedersen K. Arch. Dermatol. Res., 280:83–89, 1988.

    Article  PubMed  CAS  Google Scholar 

  54. Sprecher E. and Becker Y. Arch Virol., 103:1–14, 1988.

    Article  PubMed  CAS  Google Scholar 

  55. Streilein J.W., Lonsberry L.W. and Bergstresser P.R. J. Exp. Med., 155:863–871, 1982.

    Article  PubMed  CAS  Google Scholar 

  56. Sprecher E. and Becker Y. Arch.Virol., 91:341–349, 1986.

    Article  PubMed  CAS  Google Scholar 

  57. Haar J.L., Popp J.D. and Shultz L.D. Exp. Hematol., 17:21–29, 1989.

    PubMed  CAS  Google Scholar 

  58. Fink P.J., Gallatin W.M., Reichert R.A., Butcher E.C. and Weissman I.L. Nature, 313:233–235, 1985.

    Article  PubMed  CAS  Google Scholar 

  59. Medlock E.S., Goldshneider I., Greiner D.L. and Shultz L.D. J. Immunol., 138:3590–3597, 1987.

    PubMed  CAS  Google Scholar 

  60. Hayashi S.I., Witte P.L., Shultz L.D. and Kincade P.W. J. Immunol., 140:2139–2147, 1988.

    PubMed  CAS  Google Scholar 

  61. Jenkinson E.J. and Owen J.J.T. Progress in Immunology, vol.VI, pp.67–76, 1986.

    Google Scholar 

  62. Shiohara T., Moriya N., Saizawa K.M. and Nagashima M. Arch. Dermatol. Res., 280:33–38, 1988.

    Article  PubMed  CAS  Google Scholar 

  63. Jenkinson E.J., Van Ewijk W. and Owen J.J.T. J. Exp. Med., 153:280–292, 1981.

    Article  PubMed  CAS  Google Scholar 

  64. MacDonald H.R., Blanc C., Lees R.K. and Sordat B. J. Immunol., 136:4337–4339, 1986.

    PubMed  CAS  Google Scholar 

  65. English P.E., Wiedmeier S.E., Roberts L.K., Araneo B.A., Daynes R.A. and Krueger G.G. J. Invest. Dermatol., 88:487, 1987.

    Google Scholar 

  66. Koning F., Stingl G., Yokoyama W.M., Yamada H., Maloy W.L., Tschachler E., Shevach E.M. and Coligan J.E. Science, 236:834–837, 1987.

    Article  PubMed  CAS  Google Scholar 

  67. Pardoll D.M., Fowlkes B.J., Bluestone J.A., Kruisbeek A., Maloy W.L. Nature, 326:79–81, 1987.

    Article  PubMed  CAS  Google Scholar 

  68. Havran W.L. and Allison J.P. Nature, 335:443–445, 1988.

    Article  PubMed  CAS  Google Scholar 

  69. Yoshikai Y., Matsuzaki G., Takeda Y., Ohga S., Kishihara K., Yuuki H. and Nomoto K. Eur. J. Immunol., 18:1039–1043, 1988.

    Article  PubMed  CAS  Google Scholar 

  70. Payer E., Steiner G., Honjo M., Elbe A. and Stingl G. J. Invest. Dermatol., 92:498, 1989.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University, 91010, Jerusalem, Israel

    Eli Sprecher & Yechiel Becker

  2. The Jackson Laboratory, Bar Harbor, Maine, 04609, USA

    Leonard D. Shultz

Authors
  1. Eli Sprecher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leonard D. Shultz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yechiel Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hebrew University, Jerusalem, Israel

    Yechiel Becker

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sprecher, E., Shultz, L.D., Becker, Y. (1991). Epidermal Dendritic Cells in Immunodeficient Mice. In: Becker, Y. (eds) Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. Developments in Medical Virology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3942-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3942-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6759-8

  • Online ISBN: 978-1-4615-3942-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation