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Involvement of Epidermal and Lymph Node Dendritic Cells in Skin HSV-1 Infection

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Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS

Part of the book series: Developments in Medical Virology ((DIMV,volume 7))

Abstract

The present article analyzes the role of Langerhans cells (LC) in the defense of the murine skin against herpes simplex virus type 1 (HSV-1) infection. Intradermal infection with HSV-1 resulted in an increase in LC numbers. Activation and increase in LC density by a streptococcal preparation, OK-432, was accompanied by a striking decrease in HSV-1-induced mortality in infected mice. Decrease in LC density led to an increase in the virulence of the virus and synthesis of viral DNA in the brain and the mouse footpad skin. LC were found to induce proliferation of HSV-1-sensitized T cells in vitro in the presence of the virus and were able to transfer viral material from the skin to the draining lymph nodes. HSV-1-sensitized T cells could be recovered from the draining lymph nodes following immunization in the footpad skin with live virus, but not when the immunizing virus was injected into the skin after depletion of LC.

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Authors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University, 91010, Jerusalem, Israel

    Eli Sprecher & Yechiel Becker

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  1. Eli Sprecher
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  2. Yechiel Becker
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  1. Hebrew University, Jerusalem, Israel

    Yechiel Becker

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Sprecher, E., Becker, Y. (1991). Involvement of Epidermal and Lymph Node Dendritic Cells in Skin HSV-1 Infection. In: Becker, Y. (eds) Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. Developments in Medical Virology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3942-1_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3942-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6759-8

  • Online ISBN: 978-1-4615-3942-1

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