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Purged Autologous Bone Marrow: Better or Worse than Circulating Stem Cells?

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Book cover Advances in haemapheresis

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 25))

Abstract

Autologous bone marrow tranplantation (ABMT) has been extensively used as treatment for hematological malignancies over the last decade [1]. The main cause of failure after ABMT is relapse or recurrence of the underlying disease which at least in some cases could be due to the reinfusion of malignant cells present in the marrow inoculum. Thus,different methods of purging, using immunological, physical or chemical techniques were proposed for “ex vivo” treatment of bone marrow cells. Recently peripheral blood stem cells (PBSC) were demonstrated to be able to reconstitute complete and stable hematopoiesis following supralethal therapy [2]. It has been hypothesized that PBSC may be less contaminated by residual tumor cells than bone marrow cells.Thus, autologous blood stem cell transplantation (ABSCT) could be used instead of (purged or unpurged) ABMT.

Supported in part by a grant from the Conseil Regional d’ Aquitaine and the Association pour la Recherche contre le Cancer.

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Authors
  1. J. Reiffers
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga

  2. University Hospital Utrecht, The Netherlands

    L. Kater

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© 1991 Springer Science+Business Media Dordrecht

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Reiffers, J. (1991). Purged Autologous Bone Marrow: Better or Worse than Circulating Stem Cells?. In: Sibinga, C.T.S., Kater, L. (eds) Advances in haemapheresis. Developments in Hematology and Immunology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3904-9_13

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  • DOI: https://doi.org/10.1007/978-1-4615-3904-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6742-0

  • Online ISBN: 978-1-4615-3904-9

  • eBook Packages: Springer Book Archive

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